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Three New Anti-Rotavirus Chromeno[3,2-
Heterocycles ( IF 0.6 ) Pub Date : 2021-07-06 , DOI: 10.3987/com-21-14505
Guang-Yu Yang , Yin-Ke Li , Qiu-Fen Hu , Fan Wu , Tao Zhou , Min Zhou , Ya-Ning Zhu , Bing-Biao Cai , Ming-Xin Liu , Man-Fei Li

Three new chromeno[3,2-c]pyridines (1-3) were isolated from the whole plants of Thalictrum scabrifolium. Their structures were elucidated by spectroscopic methods, including extensive 1H, 13C, and 2D-NMR techniques. Compounds 1-3 were also tested for their anti-rotavirus activity, and they exhibited potent anti-rotavirus activity with therapeutic index (TI) valves of 23.7, 18.3, and 19.2 respectively.

中文翻译:

三款新型抗轮状病毒Chromeno[3,2-

三个新的色烯并[3,2- Ç ]吡啶(1 - 3 )从全植物中分离唐松scabrifolium 它们的结构通过光谱方法阐明,包括广泛的1 H、13 C 和 2D-​​NMR 技术。化合物1 - 3还测试了它们的抗轮状病毒活性,并且它们表现出与23.7治疗指数(TI)阀,18.3,和19.2分别有效的抗轮状病毒活性。
更新日期:2021-07-06
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