For its unique role in developing and designing new bioactive materials and healthcare products, fluoro-organic compounds have attracted remarkable interest. Along with ever-increasing demand for a wider availability of fluorine-containing structural units, a large diversity of methods has been introduced to incorporate fluorine atoms specially in a stereoselective fashion. Among them, catalytic Mannich reaction can proceed with a broad variety of reactants and open clear paths for the synthesis of versatile amine synthons in the synthesis of natural product and pharmaceutical molecules. This review provides an overview of the employment of catalytic asymmetric Mannich reactions in the synthesis of fluorine-containing amine compounds and highlights the conceivable distinct mechanisms.

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中文翻译：

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用于构建含氟化合物的催化立体选择性曼尼希型反应

由于在开发和设计新的生物活性材料和保健产品方面的独特作用，氟有机化合物引起了极大的兴趣。随着对更广泛的含氟结构单元可用性的需求不断增加，已经引入了多种方法来特别以立体选择性方式结合氟原子。其中，催化曼尼希反应可以与多种反应物一起进行，为天然产物和药物分子合成中多功能胺合成子的合成开辟了清晰的路径。本综述概述了催化不对称曼尼希反应在合成含氟胺化合物中的应用，并强调了可能的不同机制。

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