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Homeostatic control of redox status and health
IUBMB Life ( IF 4.6 ) Pub Date : 2021-07-06 , DOI: 10.1002/iub.2519
Helmut Sies 1, 2 , Fulvio Ursini 3
Affiliation  

Research on oxidants and electrophiles has shifted from focusing on damage to biomolecules to the more fine-grained physiological arena. Redox transitions as excursions from a steady-state redox set point are continually ongoing in maintenance of redox balance. Current excitement on these topics results from the fact that recent research provided mechanistic insight, which gives rise to more concrete and differentiated questions. This Commentary focuses on redox eustress and the feedback restoration of steady state as concepts in active maintenance of physiological health, with brief discussion of redox stress response to viral infection, exemplified by COVID-19.

中文翻译:

氧化还原状态和健康的稳态控制

对氧化剂和亲电子试剂的研究已经从关注对生物分子的损害转向更细粒度的生理领域。作为从稳态氧化还原设定点偏移的氧化还原转变在维持氧化还原平衡的过程中不断进行。当前对这些主题的兴奋源于最近的研究提供了机械洞察力,这引发了更具体和不同的问题。本评论侧重于氧化还原正常应激和稳态反馈恢复作为积极维护生理健康的概念,并简要讨论了氧化还原应激对病毒感染的反应,以 COVID-19 为例。
更新日期:2021-07-06
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