Micelles from self-assembled amphiphilic copolymers are highly attractive in drug delivery, due to their small size and hydrophilic stealth corona allowing prolonged lifetimes in the bloodstream and thus improved drug bioavailability. Polylactide (PLA)-based amphiphilic copolymer micelles are key candidates in this field, owing to the well-established biodegradability and biocompatibility of PLA. While PLA-b-poly(ethylene glycol) (PEG) block copolymer micelles can be seen as the “gold standard” in drug delivery research so far, the progresses in controlled radical polymerizations (Atom Transfer Radical Polymerization, Reversible Addition-Fragmentation Transfer and Nitroxide Mediated Polymerization) have offered new opportunities in the design of advanced amphiphilic copolymers for drug delivery due to their flexibility in many regards: (i) they can be easily combined with ring-opening polymerization (ROP) of lactide, with a diversity in types of architectures (e.g., block, graft, star), (ii) they allow (co)polymerization of a wide range of vinyl monomers, possibly circumventing PEG limitations, (iii) functionalization (with biomolecules or stimuli-cleavable moieties) is versatile due to end-group fidelity and copolymerization ability with reactive/functional comonomers. In this review, we report on the advances in the past decade of such amphiphilic PLA/vinyl polymer based nano-carriers, regarding key properties such as stealth character, cell targeting and stimuli-responsiveness.

来自自组装两亲共聚物的胶束在药物递送方面极具吸引力，因为它们的尺寸小且亲水性隐形电晕允许延长血液中的寿命，从而提高药物的生物利用度。由于 PLA 良好的生物降解性和生物相容性，基于聚乳酸 (PLA) 的两亲共聚物胶束是该领域的关键候选物。迄今为止，PLA-b-聚（乙二醇）（PEG）嵌段共聚物胶束可被视为药物递送研究的“黄金标准”，而可控自由基聚合（原子转移自由基聚合、可逆加成-断裂转移和氮氧化合物介导的聚合）为设计用于药物递送的先进两亲共聚物提供了新的机会，因为它们在许多方面具有灵活性：例如，嵌段、接枝、星形），（ii）它们允许（共）聚合广泛的乙烯基单体，可能绕过 PEG 限制，（iii）功能化（具有生物分子或刺激可裂解的部分）由于末端 -基团保真度和与反应性/功能性共聚单体的共聚能力。在这篇综述中，我们报告了这种基于两亲性 PLA/乙烯基聚合物的纳米载体在过去十年中在隐身特性、细胞靶向和刺激响应等关键特性方面的进展。