Objective

Healing of soft tissues and improvement of aesthetics have become major research objectives in implantology and renewed the interest for ceramics implants. The aim of this study was to evaluate the pre-clinical performance of screw-shaped sandblasted-etched implants processed from an innovative zirconia-based ceramic composite, in comparison to titanium.

Methods

Twenty-four ceramic and twenty-four titanium screw-shaped sandblasted-etched dental implants were tested in a split-mouth design in six Beagle dogs. Surface topographies were investigated by confocal microscopy. Local tissue effects were evaluated at 4 and 13 weeks after implantation through histology. An ANOVA statistical analysis (5% risk; p < 0.05) was performed to compare peri-implant quantitative histomorphometric parameters on buccal and lingual sides, including Bone to Implant Contact (BIC) among test groups and time-periods.

Results

Titanium and ceramic implants presented respectively moderate and minimal roughness. After 4 and 13 weeks, ceramic implants showed an inflammatory tissue response close to titanium implants. At both period of time there was no significant difference between the titanium and ceramic groups in terms of BIC values (mean ± SD) at the lingual or buccal sides or when combining buccal + lingual BIC values (respectively for titanium and ceramic, 68.4 ± 14.7 % and 75.0 ± 13.5 % at 4 weeks, and 92.0 ± 8.6 % and 86.1 ± 13.8 % at 13 weeks).

Significance

Within the limits of the present study, it can be concluded that newly developed zirconia-based ceramic composite dental implants have similar biocompatibility and osseointegration to those observed in titanium implants. These pre-clinical results corroborate the potential for the use of these new zirconia-based ceramics in oral implantology.

中文翻译：

---

新型氧化锆陶瓷牙种植体的组织学和组织形态学评估：犬的临床前研究

客观的

软组织的愈合和美学的改善已成为种植学的主要研究目标，并重新引起了对陶瓷种植体的兴趣。本研究的目的是评估由创新的氧化锆基陶瓷复合材料加工而成的螺旋形喷砂蚀刻植入物与钛相比的临床前性能。

方法

24 个陶瓷和 24 个钛螺丝形喷砂蚀刻牙种植体在六只比格犬的分口设计中进行了测试。通过共聚焦显微镜研究表面形貌。在植入后 4 周和 13 周时通过组织学评估局部组织效应。进行方差分析（5% 风险；p < 0.05）以比较颊侧和舌侧的种植体周围定量组织形态学参数，包括测试组和时间段之间的骨与种植体接触 (BIC)。

结果

钛和陶瓷植入物分别呈现中等和最小粗糙度。4 周和 13 周后，陶瓷植入物显示出接近钛植入物的炎症组织反应。在这两个时间段内，钛和陶瓷组在舌侧或颊侧的 BIC 值（平均值±SD）或结合颊+舌侧 BIC 值（钛和陶瓷分别为 68.4 ± 14.7）方面没有显着差异% 和 75.0 ± 13.5 % 在第 4 周，92.0 ± 8.6 % 和 86.1 ± 13.8 % 在第 13 周）。

意义

在本研究的范围内，可以得出结论，新开发的氧化锆基陶瓷复合牙种植体具有与钛种植体中观察到的相似的生物相容性和骨整合。这些临床前结果证实了这些新型氧化锆陶瓷在口腔种植学中的应用潜力。