The present research aimed to examine the biological properties of chitosan (CS)–polyvinyl alcohol (PVA) scaffolds reinforced with graphene oxide (GO) nanosheets, as wound dressings. The scaffolds were characterized by various techniques. The scanning electron microscopy (SEM) and thermogravimetry analyses (TGAs) were used to investigate distribution of the GO within the polymer. The viscoelastic properties were evaluated by dynamic mechanical thermal analysis (DMTA) to examine the quality of a wound dressing. In vitro and in vivo studies were conducted to assess the biocompatibility of the scaffolds as wound dressing. The cell viability and proliferation results indicated that mouse fibroblast cells (L929) could adhere on the 50CS–50PVA/3 wt% GO scaffold. Herewith, the fabricated CS–PVA–GO nanocomposite scaffolds are suggested as promising biomaterials for skin tissue engineering and wound dressing.

本研究旨在研究用氧化石墨烯 (GO) 纳米片增强的壳聚糖 (CS)-聚乙烯醇 (PVA) 支架作为伤口敷料的生物学特性。支架通过各种技术表征。使用扫描电子显微镜 (SEM) 和热重分析 (TGA) 来研究 GO 在聚合物中的分布。通过动态机械热分析 (DMTA) 评估粘弹性，以检查伤口敷料的质量。进行了体外和体内研究以评估支架作为伤口敷料的生物相容性。细胞活力和增殖结果表明小鼠成纤维细胞 (L929) 可以粘附在 50CS–50PVA/3 wt% GO 支架上。特此，