The gut microbiota is known to play a role in various disease states through inflammatory, immune and endocrinologic response. Parkinson’s Disease is of particular interest as gastrointestinal involvement is one of the earlier features seen in this disease. This paper examines the relationship between gut microbiota and Parkinson’s Disease, which has a growing body of literature. Inflammation caused by gut dysbiosis is thought to increase a-synuclein aggregation and worsen motor and neurologic symptoms of Parkinson’s disease. We discuss potential treatment and supplementation to modify the microbiota. Some of these treatments require further research before recommendations can be made, such as cord blood transplant, antibiotic use, immunomodulation and fecal microbiota transplant. Other interventions, such as increasing dietary fiber, polyphenol and fermented food intake, can be made with few risks and may have some benefit for symptom relief and speed of disease progression.

众所周知，肠道微生物群通过炎症、免疫和内分泌反应在各种疾病状态中发挥作用。帕金森病是特别令人感兴趣的，因为胃肠道受累是这种疾病的早期特征之一。本文研究了肠道微生物群与帕金森氏病之间的关系，帕金森氏病的文献越来越多。由肠道菌群失调引起的炎症被认为会增加 a-突触核蛋白的聚集并加重帕金森病的运动和神经系统症状。我们讨论了改变微生物群的潜在治疗和补充。其中一些治疗方法需要进一步研究才能提出建议，例如脐带血移植、抗生素使用、免疫调节和粪便微生物群移植。其他干预措施，例如增加膳食纤维，