Abstract

Background

This study aimed to assess the reliability of pressure derived fractional flow reserve (FFR) measurement and the handling performance of the OptoWire Deux with an optical pressure sensor relative to both the PressureWire X and the Verrata Pressure wire with piezoresistive pressure sensors.

Methods

This single centre study included 80 patients between October 2016 and May 2017 undergoing a diagnostic coronary angiography. The reliability of FFR measurement measured with the OptoWire Deux relative to the PressureWire X and Verrata Pressure wire was assessed by the presence of drift. Drift was defined as a Pd/Pa measurement different from 1.00 ± 0.02 when pulled back after a FFR measurement at the location of the initial equalisation. Handling characteristics for all pressure wires were assessed qualitatively with respect to the PressureWire Aeris.

Results

Ninety-eight measurements in 78 patients were performed; two patients were excluded because the lesion could not be crossed. Very stable and reliable FFR measurements with the optical sensors were registered, relative to the piezoresistive pressure sensors. Drift was found in 11%, 37%, and 33% of the measurements for OptoWire Deux, PressureWire X, and Verrata Pressure wire respectively. The handling performance of the OptoWire Deux was better rated for steerability and torqueability in relation to the standard FFR wire. The handling of the PressureWire X was rated equally good whereas the handling of the Verrata pressure wire was rated inferior in relation to the standard FFR wire.

Conclusions

In patients undergoing FFR measurement, the OptoWire Deux has a stable and reliable pressure hence FFR measurement with fewer drift events and has good handling characteristics.

中文翻译：

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FFR 压力线比较研究：压阻式与光学传感器

摘要

背景

本研究旨在评估压力衍生的部分流量储备 (FFR) 测量的可靠性以及带有光学压力传感器的 OptoWire Deux 相对于 PressureWire X 和带有压阻式压力传感器的 Verrata 压力线的处理性能。

方法

这项单中心研究包括 2016 年 10 月至 2017 年 5 月期间接受诊断性冠状动脉造影的 80 名患者。使用 OptoWire Deux 测量的 FFR 测量相对于 PressureWire X 和 Verrata 压力线的可靠性通过漂移的存在来评估。漂移定义为在初始均衡位置进行 FFR 测量后拉回时不同于 1.00 ± 0.02 的 Pd/Pa 测量值。针对 PressureWire Aeris，对所有压力线的处理特性进行了定性评估。

结果

对 78 名患者进行了 98 次测量；两名患者被排除在外，因为病变无法穿过。相对于压阻式压力传感器，记录了使用光学传感器进行的非常稳定和可靠的 FFR 测量。OptoWire Deux、PressureWire X 和 Verrata 压力线分别有 11%、37% 和 33% 的测量结果存在漂移。与标准 FFR 线材相比，OptoWire Deux 的操控性能在转向性和扭矩性方面得到了更好的评价。PressureWire X 的处理被评为同样好，而 Verrata 压力线的处理被评为低于标准 FFR 线。

结论

在进行 FFR 测量的患者中，OptoWire Deux 具有稳定可靠的压力，因此 FFR 测量具有较少的漂移事件并具有良好的处理特性。