To investigate the effectiveness of shear-wave elastography (SWE) based on e-health in diagnosing liver fibrosis in patients infected with hepatitis B virus (HBV) and provide theoretical basis for early diagnosis and treatment of patients with chronic HBV infection, in this study, 73 patients with chronic HBV infection who underwent e-health SWE examination were divided into chronic hepatitis B group (51 cases) and hepatitis B cirrhosis group (22 cases), and another 20 healthy volunteers were introduced as control. The contents of second liver two half-and-half, hyaluronic acid (HA) of liver fibrosis, laminin (LN), pAUVollagen III N terminal peptide (PIII NP), collage type IV (CIV), and HBV-DNA were detected. SWE was used to measure the elastic modulus in the S2 and S3 segments of the left outer lobe of the liver, S4 segment of the left inner lobe of the liver, S5 and S8 segments of the right anterior lobe of the liver, and S6 and S7 segments of the right posterior lobe of the liver. Finally, the correlations between the four examination results of liver fibrosis and the elastic modulus values were compared, and the receiver operator characteristic curve (ROC) for SWE technical diagnosis was drawn. The results showed that there was no significant difference in HBV-DNA content between the two groups (); the contents of alanine transaminase (ALT) and aspartate aminotransferase (AST) in the blood of chronic hepatitis B group were significantly higher than those in the liver cirrhosis group (); HA, PIII NP, and CIV contents were significantly lower than the liver cirrhosis group (); the success rates of SWE detection in S5 and S6 segments of the two groups were 100.00%, and the elastic modulus of the hepatitis B cirrhosis group was significantly higher than that of the chronic hepatitis B group (); correlation results showed HA, PIII NP, and CIV of two groups of patients and elastic modulus value in S5 and S6 segments showed positive correlation (); ROC curve analysis showed that AUC (area under the curve) was 0.866, the sensitivity was 89.59%, and the specificity was 76.49%, which indicated that the liver elastic modulus value measured by e-health SWE technology can quantitatively show liver fibrosis in patients with chronic HBV infection, and its application in the diagnosis of clinical liver fibrosis was real and feasible.

中文翻译：

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慢性乙型肝炎病毒感染肝纤维化实时剪切波弹性成像信息健康监测的接收器操作特征 (ROC) 分析

探讨基于e-health的剪切波弹性成像（SWE）在诊断乙型肝炎病毒（HBV）感染患者肝纤维化中的有效性，为慢性HBV感染患者的早期诊断和治疗提供理论依据。将73例接受e-health SWE检查的慢性HBV感染患者分为慢性乙型肝炎组（51例）和乙型肝炎肝硬化组（22例），另引入20名健康志愿者作为对照。检测第二肝二半、肝纤维化透明质酸（HA）、层粘连蛋白（LN）、pAUVollagen III N末端肽（PIII NP）、IV型胶原（CIV）、HBV-DNA的含量。SWE用于测量肝脏左外叶S2和S3段的弹性模量，肝左内叶S4段，右肝前叶S5和S8段，右肝后叶S6和S7段。最后比较4项肝纤维化检查结果与弹性模量值的相关性，绘制SWE技术诊断的受试者工作特征曲线（ROC）。结果显示，两组间HBV-DNA含量无显着差异（); 慢性乙型肝炎组血液中丙氨酸转氨酶（ALT）和天冬氨酸转氨酶（AST）的含量显着高于肝硬化组（); HA、PIII NP、CIV含量显着低于肝硬化组（); 两组S5、S6段SWE检测成功率均为100.00%，乙肝肝硬化组弹性模量明显高于慢性乙肝组（); 相关性结果显示，两组患者的HA、PIII NP、CIV与S5、S6节段弹性模量值呈正相关（); ROC曲线分析显示AUC（曲线下面积）为0.866，敏感性为89.59%，特异性为76.49%，说明e-health SWE技术测得的肝脏弹性模量值可以定量显示患者的肝纤维化慢性HBV感染者，其在临床肝纤维化诊断中的应用是真实可行的。