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pH/enzyme/light triple-responsive vesicles from lysine-based amphiphilic diblock copolymers
Journal of Polymer Science ( IF 3.4 ) Pub Date : 2021-07-04 , DOI: 10.1002/pol.20210245 Guoyang Qin 1 , Cong Hu 1 , Yanfen Jiang 1 , Shuqi Dong 1 , Li Liu 1 , Hanying Zhao 1, 2
Journal of Polymer Science ( IF 3.4 ) Pub Date : 2021-07-04 , DOI: 10.1002/pol.20210245 Guoyang Qin 1 , Cong Hu 1 , Yanfen Jiang 1 , Shuqi Dong 1 , Li Liu 1 , Hanying Zhao 1, 2
Affiliation
We report the synthesis of pH- and enzyme-responsive amphiphilic diblock copolymers through reversible addition-fragmentation chain transfer polymerization of a lysine-derived methacrylate monomer comprising p-nitrobenzyl carbamate (pNBC) functionality using a poly(ethylene glycol)-modified macro-chain transfer agent. Depending on the hydrophobic block length, the diblock copolymers self-assemble to form spherical micelles, wormlike micelles, and bilayered vesicles in the aqueous solution. The responsive behaviors of the polymeric vesicles to pH, enzyme, and light are investigated in detail. As the pH lowers to pH 5.0, the polymeric vesicles undergo a morphological transition from vesicles to spherical micelles. In the presence of nitroreductase and a cofactor NADH, the decomposition of pNBC releases the ε-NH2 of the lysine moiety and hence induces the generation of the vesicles with crosslinked membranes at pH 7.4. Moreover, owing to the degradation of pNBC moiety under UV irradiation, the polymeric vesicles also demonstrate a photo-responsive feature. As the irradiation time prolongs, it is observed a light-triggered morphological transition from vesicles to wormlike micelles with network-like structures.
中文翻译:
来自基于赖氨酸的两亲性二嵌段共聚物的 pH/酶/光三响应囊泡
我们报告了通过包含对硝基苄基氨基甲酸酯 ( pNBC)使用聚(乙二醇)改性的大链转移剂的功能。根据疏水性嵌段长度,二嵌段共聚物自组装以在水溶液中形成球形胶束、蠕虫状胶束和双层囊泡。详细研究了聚合物囊泡对 pH、酶和光的响应行为。随着 pH 值降低到 5.0,聚合物囊泡经历了从囊泡到球形胶束的形态转变。在硝基还原酶和辅助因子 NADH 的存在下,p NBC的分解释放赖氨酸部分的 ε-NH 2,因此在 pH 7.4 时诱导产生具有交联膜的囊泡。此外,由于p的降解NBC 部分在紫外线照射下,聚合物囊泡也表现出光响应特征。随着照射时间的延长,观察到从囊泡到具有网络状结构的蠕虫状胶束的光触发形态转变。
更新日期:2021-09-01
中文翻译:
来自基于赖氨酸的两亲性二嵌段共聚物的 pH/酶/光三响应囊泡
我们报告了通过包含对硝基苄基氨基甲酸酯 ( pNBC)使用聚(乙二醇)改性的大链转移剂的功能。根据疏水性嵌段长度,二嵌段共聚物自组装以在水溶液中形成球形胶束、蠕虫状胶束和双层囊泡。详细研究了聚合物囊泡对 pH、酶和光的响应行为。随着 pH 值降低到 5.0,聚合物囊泡经历了从囊泡到球形胶束的形态转变。在硝基还原酶和辅助因子 NADH 的存在下,p NBC的分解释放赖氨酸部分的 ε-NH 2,因此在 pH 7.4 时诱导产生具有交联膜的囊泡。此外,由于p的降解NBC 部分在紫外线照射下,聚合物囊泡也表现出光响应特征。随着照射时间的延长,观察到从囊泡到具有网络状结构的蠕虫状胶束的光触发形态转变。