当前位置: X-MOL 学术J. Gynecol. Oncol. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Efficacy and safety of intravenous administration of high-dose selenium for preventing chemotherapy-induced peripheral neuropathy in platinum-sensitive recurrent ovarian, fallopian or primary peritoneal cancer: study protocol for a phase III, double-blind, randomized study.
Journal of Gynecologic Oncology ( IF 3.9 ) Pub Date : 2021-06-01 , DOI: 10.3802/jgo.2021.32.e73
Soo Jin Park 1 , Ga Won Yim 2 , Haerin Paik 1 , Nara Lee 3 , Seungmee Lee 4 , Maria Lee 1 , Hee Seung Kim 1
Affiliation  

The second-line chemotherapy using paclitaxel, carboplatin, and bevacizumab for treating platinum-sensitive recurrent ovarian, fallopian or primary peritoneal cancer frequently cause chemotherapy-induced peripheral neuropathy (CIPN), which is significantly associated with deterioration of quality of life. Despite the potential of some agents to prevent and treat CIPN, and there is still a lack of evidence of the effect. Although selenium has been suggested as an antioxidant candidate to prevent CIPN, there are insufficient data regarding its effect due to its low dose by oral administration. Thus, we hypothesized intravenous administration of high-dose selenium (2,000 μg/day) at each cycle of the second-line chemotherapy would prevent and reduce CIPN in patients with platinum-sensitive recurrent ovarian, fallopian or primary peritoneal cancer.

中文翻译:

静脉注射高剂量硒预防铂敏感复发性卵巢癌、输卵管癌或原发性腹膜癌化疗引起的周围神经病变的有效性和安全性:III 期、双盲、随机研究的研究方案。

使用紫杉醇、卡铂和贝伐单抗治疗铂敏感复发性卵巢癌、输卵管癌或原发性腹膜癌的二线化疗经常引起化疗引起的周围神经病变(CIPN),这与生活质量的恶化显着相关。尽管某些药剂具有预防和治疗 CIPN 的潜力,但仍缺乏效果的证据。尽管硒被认为是预防 CIPN 的抗氧化剂候选物,但由于其口服剂量低,因此关于其效果的数据不足。因此,我们假设在二线化疗的每个周期静脉注射高剂量硒(2,000 μg/天)可以预防和减少铂敏感复发性卵巢癌、输卵管癌或原发性腹膜癌患者的 CIPN。
更新日期:2021-07-06
down
wechat
bug