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Strategy for fast manufacturing of 3D hydrodynamic focusing multilayer microfluidic chips and its application for flow-based synthesis of gold nanoparticles
Microfluidics and Nanofluidics ( IF 2.8 ) Pub Date : 2021-07-05 , DOI: 10.1007/s10404-021-02463-6
Yanwei Wang 1 , Michael Seidel 1
Affiliation  

Fabrication of 3D microfluidic devices is normally quite expensive and tedious. A strategy was established to rapidly and effectively produce multilayer 3D microfluidic chips which are made of two layers of poly(methyl methacrylate) (PMMA) sheets and three layers of double-sided pressure sensitive adhesive (PSA) tapes. The channel structures were cut in each layer by cutting plotter before assembly. The structured channels were covered by a PMMA sheet on top and a PMMA carrier which contained threads to connect with tubing. A large variety of PMMA slides and PSA tapes can easily be designed and cut with the help of a cutting plotter. The microfluidic chip was manually assembled by a simple lamination process.The complete fabrication process from device design concept to working device can be completed in minutes without the need of expensive equipment such as laser, thermal lamination, and cleanroom. This rapid frabrication method was applied for design of a 3D hydrodynamic focusing device for synthesis of gold nanoparticles (AuNPs) as proof-of-concept. The fouling of AuNPs was prevented by means of a sheath flow. Different parameters such as flow rate and concentration of reagents were controlled to achieve AuNPs of various sizes. The sheet-based fabrication method offers a possibility to create complex microfluidic devices in a rapid, cheap and easy way.



中文翻译:

3D流体动力聚焦多层微流控芯片的快速制造策略及其在金纳米粒子的流动合成中的应用

3D 微流体装置的制造通常非常昂贵和乏味。建立了一种快速有效地生产多层 3D 微流控芯片的策略,该芯片由两层聚甲基丙烯酸甲酯 (PMMA) 片材和三层双面压敏胶 (PSA) 胶带制成。组装前用刻字机在每一层切割通道结构。结构化通道由顶部的 PMMA 板和 PMMA 载体覆盖,该载体包含与管道连接的螺纹。在刻字机的帮助下,可以轻松设计和切割各种 PMMA 载玻片和 PSA 胶带。微流控芯片是通过简单的层压过程手动组装的。从器件设计概念到工作器件的完整制造过程可以在几分钟内完成,无需昂贵的设备,如激光、热层压和洁净室。这种快速粉碎方法用于设计用于合成金纳米粒子 (AuNPs) 的 3D 流体动力学聚焦装置作为概念验证。通过鞘流防止了 AuNPs 的污染。控制不同的参数,如流速和试剂浓度,以实现各种尺寸的 AuNP。基于片的制造方法提供了以快速、廉价和简单的方式创建复杂微流体设备的可能性。这种快速粉碎方法用于设计用于合成金纳米粒子 (AuNPs) 的 3D 流体动力学聚焦装置作为概念验证。通过鞘流防止了 AuNPs 的污染。控制不同的参数,如流速和试剂浓度,以实现各种尺寸的 AuNP。基于片的制造方法提供了以快速、廉价和简单的方式创建复杂微流体设备的可能性。这种快速粉碎方法用于设计用于合成金纳米粒子 (AuNPs) 的 3D 流体动力学聚焦装置作为概念验证。通过鞘流防止了 AuNPs 的污染。控制不同的参数,如流速和试剂浓度,以实现各种尺寸的 AuNP。基于片的制造方法提供了以快速、廉价和简单的方式创建复杂微流体设备的可能性。

更新日期:2021-07-05
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