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Gamma oscillations modulate working memory recall precision
Experimental Brain Research ( IF 2 ) Pub Date : 2021-07-05 , DOI: 10.1007/s00221-021-06051-6
Lyall Thompson 1 , Janine Khuc 1 , Maria Silvia Saccani 1 , Nahid Zokaei 2, 3 , Marinella Cappelletti 1, 4
Affiliation  

Working memory (WM)—the ability to keep information in mind for short periods of time—is linked to attention and inhibitory abilities, i.e., the capacity to ignore task-irrelevant information. These abilities have been associated with brain oscillations, especially parietal gamma and alpha bands, but it is yet unknown whether these oscillations also modulate attention and inhibitory abilities. To test this, we compared parietal gamma-transcranial alternating current stimulation (tACS) to alpha-tACS and to a non-stimulation condition (Sham) in 51 young participants. Stimulation was coupled with a WM task probing memory-based attention and inhibitory abilities by means of probabilistic retrospective cues, including informative (valid), uninformative (invalid) and neutral. Our results show that relative to alpha and sham stimulation, parietal gamma-tACS significantly increased working memory recall precision. Additional post hoc analyses also revealed strong individual variability before and following stimulation; low-baseline performers showed no significant changes in performance following both gamma and alpha-tACS relative to sham. In contrast, in high-baseline performers gamma- (but not alpha) tACS selectively and significantly improved misbinding-feature errors as well as memory precision, particularly in uninformative (invalid) cues which rely more strongly on attentional abilities. We concluded that parietal gamma oscillations, therefore, modulate working memory recall processes, although baseline performance may further influence the effect of stimulation.



中文翻译:

伽马振荡调节工作记忆召回精度

工作记忆(WM)——在短时间内记住信息的能力——与注意力和抑制能力有关,即忽略与任务无关信息的能力。这些能力与大脑振荡有关,尤其是顶叶伽马和阿尔法波段,但尚不清楚这些振荡是否也调节注意力和抑制能力。为了测试这一点,我们比较了 51 名年轻参与者的顶叶伽马经颅交流电刺激 (tACS) 与 alpha-tACS 和非刺激条件 (Sham)。刺激与 WM 任务相结合,通过概率回顾性线索(包括信息性(有效)、非信息性(无效)和中性)探索基于记忆的注意力和抑制能力。我们的结果表明,相对于 alpha 和假刺激,顶叶 gamma-tACS 显着提高了工作记忆的召回精度。额外的事后分​​析也揭示了刺激前后强烈的个体差异。相对于假手术,低基线表现者在 gamma 和 alpha-tACS 之后的表现没有显着变化。相比之下,在高基线执行者中,γ-(但不是 α)tACS 选择性地显着改善了错误绑定特征错误以及记忆精度,特别是在更强烈依赖注意力能力的无信息(无效)线索中。因此,我们得出结论,顶叶伽马振荡调节工作记忆回忆过程,尽管基线表现可能会进一步影响刺激的效果。额外的事后分​​析也揭示了刺激前后强烈的个体差异。相对于假手术,低基线表现者在 gamma 和 alpha-tACS 之后的表现没有显着变化。相比之下,在高基线执行者中,γ-(但不是 α)tACS 选择性地显着改善了错误绑定特征错误以及记忆精度,特别是在更强烈依赖注意力能力的无信息(无效)线索中。因此,我们得出结论,顶叶伽马振荡调节工作记忆回忆过程,尽管基线表现可能会进一步影响刺激的效果。额外的事后分​​析也揭示了刺激前后强烈的个体差异。相对于假手术,低基线表现者在 gamma 和 alpha-tACS 之后的表现没有显着变化。相比之下,在高基线执行者中,γ-(但不是 α)tACS 选择性地显着改善了错误绑定特征错误以及记忆精度,特别是在更强烈依赖注意力能力的无信息(无效)线索中。因此,我们得出结论,顶叶伽马振荡调节工作记忆回忆过程,尽管基线表现可能会进一步影响刺激的效果。在高基线执行者中,γ-(但不是 alpha)tACS 选择性地显着改善了错误绑定特征错误以及记忆精度,特别是在更强烈依赖注意力能力的无信息(无效)线索中。因此,我们得出结论,顶叶伽马振荡调节工作记忆回忆过程,尽管基线表现可能会进一步影响刺激的效果。在高基线执行者中,γ-(但不是 alpha)tACS 选择性地显着改善了错误绑定特征错误以及记忆精度,特别是在更强烈依赖注意力能力的无信息(无效)线索中。因此,我们得出结论,顶叶伽马振荡调节工作记忆回忆过程,尽管基线表现可能会进一步影响刺激的效果。

更新日期:2021-07-05
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