Neuro-ethological studies conducted by Panksepp and his colleagues have provided an understanding of how the activity of the mesolimbic dopaminergic (ML DA) system leads to the emotional disposition to SEEK/Explore, which is involved in all appetitive motivated behavior and mental activity. In pathological addiction phenomena, this emotional disposition "fixes" itself on certain obsessive-compulsive habits, losing its versatility and its natural predisposition to spontaneous and unconditioned activation. Overall, the result is a consistent disinterest in everything that is not the object of addiction. From a neuro-psycho-evolutionary point of view, the predisposition to develop addictive behavior can be attributed to a loss of “functional autonomy” of the SEEKING/Explorative disposition. Indeed, as shown by animal and human studies, the tendency to be conditioned by situations and contexts that provide an immediate reward can be closely related to a deficit in the tonic endogenous activity of the ML DA-SEEKING system.

中文翻译：

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SEEKING 驱动器及其固定。成瘾病理学的神经心理社会进化方法。

Panksepp 和他的同事进行的神经行为学研究提供了对中脑边缘多巴胺能 (ML DA) 系统的活动如何导致对 SEEK/Explore 的情绪倾向的理解，这涉及所有的食欲动机行为和心理活动。在病理性成瘾现象中，这种情绪倾向“固定”在某些强迫性习惯上，失去了它的多功能性和自发和无条件激活的自然倾向。总体而言，结果是对所有不是成瘾对象的事物始终不感兴趣。从神经心理进化的角度来看，发展成瘾行为的倾向可归因于寻求/探索性倾向的“功能自主性”的丧失。事实上，正如动物和人类研究所示，