In the life sciences, including hemostasis and thrombosis, methods of structural biology have become indispensable tools for shedding light on underlying mechanisms that govern complex biological processes. Advancements of the relatively young field of computational biology have matured to a point where it is increasingly recognized as trustworthy and useful, in part due to their high space–time resolution that is unparalleled by most experimental techniques to date. In concert with biochemical and biophysical approaches, computational studies have therefore proven time and again in recent years to be key assets in building or suggesting structural models for membrane-bound forms of coagulation factors and their supramolecular complexes on membrane surfaces where they are activated. Such endeavors and the proposed models arising from them are of fundamental importance in describing and understanding the molecular basis of hemostasis under both health and disease conditions. We summarize the body of work done in this important area of research to drive forward both experimental and computational studies toward new discoveries and potential future therapeutic strategies.

在包括止血和血栓形成在内的生命科学中，结构生物学方法已成为揭示控制复杂生物过程的潜在机制的不可或缺的工具。相对年轻的计算生物学领域的进步已经成熟到越来越被认为是值得信赖和有用的，部分原因是它们的高时空分辨率是迄今为止大多数实验技术所无法比拟的。因此，与生化和生物物理方法相一致，计算研究近年来已一次又一次地证明是构建或建议用于膜结合形式的凝血因子及其在其被激活的膜表面上的超分子复合物的结构模型的关键资产。这些努力和由此产生的拟议模型对于描述和理解健康和疾病条件下止血的分子基础具有至关重要的意义。我们总结了在这一重要研究领域所做的工作，以推动实验和计算研究朝着新的发现和潜在的未来治疗策略方向发展。