Evaluation of clinical genetic services is challenging due to the nature of their interventions. The Genetic Counseling Outcome Scale (GCOS-24), a patient-reported outcome measure, was developed to measure empowerment, an important patient-reported outcome from genetic counseling. Previously, we translated and adapted GCOS-24 for use in Spain, but neither test–retest reliability nor structural and construct validity were assessed at that time. In the present study, we set out to test the reliability and validity of the Spanish adaptation of the GCOS-24 against already validated Spanish language measures of satisfaction with life, anxiety, and health locus of control. 880 patients/families who attended the genetics clinic were invited to participate in a online survey. 201 participants (23%) completed the four questionnaires at the first timepoint, and 59 of these (29%) completed GCOS-24 again the second timepoint, 2–4 weeks later. Test–retest reliability was confirmed, with no significant differences between responses to GCOS-24 at the first and second timepoints and good internal consistency. Convergent validity was confirmed between GCOS-24 and measures of satisfaction with life and anxiety but not with measures of health locus of control. For the structural and construct validation, an exploratory factor analysis was performed. The resulting factorial structure of GCOS-24 consists of 6 factors that accumulate 68% of the variance shared by the 21 items that remained in the model. We applied the factor structure of the three validated measures to the available data and analyzed the correlation between factors of GCOS-24 and the other scales. The results showed significant and consistent correlation with factors of the satisfaction with life and anxiety scales but no significant correlation with internal health locus of control. The use of the Spanish adaptation of GCOS-24 in other genetic clinics in Spain will help to validate it further. This study contributes to the international validation of GCOS-24 to evaluate the quality of genetic counseling in Europe.

中文翻译：

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遗传咨询结果量表的西班牙改编的进一步验证和心理测量学特性

由于其干预的性质，临床遗传服务的评估具有挑战性。遗传咨询结果量表 (GCOS-24) 是一种患者报告的结果测量方法，旨在衡量授权，这是遗传咨询中患者报告的重要结果。以前，我们翻译并改编了 GCOS-24 以供在西班牙使用，但当时既没有评估重测信度，也没有评估结构和结构效度。在本研究中，我们着手根据已经验证的生活满意度、焦虑和健康控制点的西班牙语测量来测试 GCOS-24 的西班牙改编版的可靠性和有效性。880 名参加遗传学诊所的患者/家庭被邀请参加在线调查。201 名参与者 (23%) 在第一个时间点完成了四份问卷，其中 59 人（29%）在 2-4 周后的第二个时间点再次完成了 GCOS-24。重测信度得到证实，在第一个和第二个时间点对 GCOS-24 的反应之间没有显着差异，并且内部一致性良好。GCOS-24 与生活满意度和焦虑测量之间的收敛效度得到证实，但与健康控制点测量之间没有得到证实。对于结构和构造验证，进行了探索性因素分析。生成的 GCOS-24 因子结构由 6 个因子组成，这些因子累积了模型中保留的 21 个项目共有的 68% 的方差。我们将三个经过验证的度量的因子结构应用于现有数据，并分析了 GCOS-24 因子与其他量表之间的相关性。结果表明，与生活满意度和焦虑量表因素显着且一致，但与内部健康控制点无显着相关性。在西班牙的其他基因诊所使用西班牙改编的 GCOS-24 将有助于进一步验证它。本研究有助于 GCOS-24 的国际验证，以评估欧洲遗传咨询的质量。