当前位置: X-MOL 学术Cell. Mol. Neurobiol. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Dendrites of Neocortical Pyramidal Neurons: The Key to Understand Intellectual Disability
Cellular and Molecular Neurobiology ( IF 4 ) Pub Date : 2021-07-03 , DOI: 10.1007/s10571-021-01123-1
Alberto Granato 1 , Adalberto Merighi 1
Affiliation  

Pyramidal neurons (PNs) are the most abundant cells of the neocortex and display a vast dendritic tree, divided into basal and apical compartments. Morphological and functional anomalies of PN dendrites are at the basis of virtually all neurological and mental disorders, including intellectual disability. Here, we provide evidence that the cognitive deficits observed in different types of intellectual disability might be sustained by different parts of the PN dendritic tree, or by a dysregulation of their interaction.



中文翻译:

新皮质锥体神经元的树突:理解智力障碍的关键

锥体神经元 (PNs) 是新皮质中最丰富的细胞,并显示出巨大的树突树,分为基底和顶端隔室。PN 树突的形态和功能异常是几乎所有神经和精神疾病的基础,包括智力障碍。在这里,我们提供的证据表明,在不同类型的智力障碍中观察到的认知缺陷可能由 PN 树突树的不同部分或它们相互作用的失调所维持。

更新日期:2021-07-04
down
wechat
bug