Atherosclerosis is one of the most dangerous forms of Cardiovascular disease (CVD) due to its asymptomatic nature during its early stages of development. The carotid sinus is a favorable location for plaque progression because of the temporal disturbances experienced in its environment. By performing a transient Fluid-Structure Interaction (FSI) on a healthy idealized carotid artery, zones of low Wall Shear Stress (WSS) were isolated as these regions are prone to plaque formation. A plaque was then constructed in the vicinity of these zones leading to lumen stenosis. The influence and variation of critical hemodynamic parameters such as WSS, Oscillatory Shear Index (OSI), and helicity were then analyzed in the stenosed artery, and compared to that of the healthy one. Significant variation in vessel deformation, an FSI exclusive parameter, was seen due to atherosclerotic obstruction near the bifurcation apex. Elevated WSS, OSI, and velocity levels were observed, especially around the sinus. Regions with low helical intensity corresponded to high particle residence times which originated at the sinus and developed well into the Internal Carotid Artery (ICA). All signs point to further progression of atherosclerosis, with high OSI and RRT indicating a further increase in the degrees of stenosis, or potential thrombus formation at the carotid sinus in case of plaque rupture due to increased velocity and WSS levels.

动脉粥样硬化是心血管疾病 (CVD) 中最危险的形式之一，因为它在发展的早期阶段无症状。颈动脉窦是斑块进展的有利位置，因为在其环境中经历了时间紊乱。通过对健康的理想颈动脉进行瞬时流体结构相互作用 (FSI)，隔离低壁剪切应力 (WSS) 区域，因为这些区域易于形成斑块。然后在这些导致管腔狭窄的区域附近构建斑块。然后在狭窄的动脉中分析关键血流动力学参数如 WSS、振荡剪切指数 (OSI) 和螺旋度的影响和变化，并与健康动脉进行比较。容器变形的显着变化，FSI 独有参数，由于分叉顶点附近的动脉粥样硬化阻塞而看到。观察到升高的 WSS、OSI 和速度水平，尤其是在窦周围。具有低螺旋强度的区域对应于高颗粒停留时间，其起源于窦并很好地发展到颈内动脉 (ICA)。所有迹象都表明动脉粥样硬化的进一步进展，高 OSI 和 RRT 表明狭窄程度进一步增加，或者在由于速度和 WSS 水平增加而导致斑块破裂的情况下，颈动脉窦可能形成血栓。具有低螺旋强度的区域对应于高颗粒停留时间，其起源于窦并很好地发展到颈内动脉 (ICA)。所有迹象都表明动脉粥样硬化的进一步进展，高 OSI 和 RRT 表明狭窄程度进一步增加，或者在由于速度和 WSS 水平增加而导致斑块破裂的情况下，颈动脉窦可能形成血栓。具有低螺旋强度的区域对应于高颗粒停留时间，其起源于窦并很好地发展到颈内动脉 (ICA)。所有迹象都表明动脉粥样硬化的进一步进展，高 OSI 和 RRT 表明狭窄程度进一步增加，或者在由于速度和 WSS 水平增加而导致斑块破裂的情况下，颈动脉窦可能形成血栓。