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The relationship of age and hypertension with cognition and gray matter cerebral blood volume in a rhesus monkey model of human aging.
Behavioral Neuroscience ( IF 1.9 ) Pub Date : 2021-07-01 , DOI: 10.1037/bne0000472
Chad W Farris 1 , Ronald J Killiany 1 , Elizabeth O'Donoghue 1 , Bang-Bon Koo 1 , Richard D Wainford 2 , Mark B Moss 1 , Douglas L Rosene 1 , Tara L Moore 1
Affiliation  

The goal of this study was to investigate whether alterations in cerebral microvasculature, as measured by cerebral blood volume (CBV), contribute to age- and hypertension-related impairments in cognitive function with a focus on executive function and memory. Data were collected on 19 male rhesus monkeys ranging from 6.4 to 21.6 years of age. Hypertension was induced through surgical coarctation of the thoracic aorta. We assessed whether performance on tasks of memory and executive function corresponded to CBV in either the hippocampus or prefrontal cortex. We found a relationship between duration of hypertension and CBV in the gray matter of the prefrontal cortex, but not the hippocampus. No relationships were found with the degree of hypertension or age. Increased prefrontal CBV was related to greater impairment in executive function while hippocampal CBV was not related to memory performance. These findings suggest that duration, but not severity, of hypertension or age are important factors underlying alterations in brain microvasculature and that executive function is more vulnerable than memory function. (PsycInfo Database Record (c) 2021 APA, all rights reserved).

中文翻译:

人类衰老恒河猴模型中年龄和高血压与认知和灰质脑血容量的关系。

本研究的目的是调查脑微血管系统的改变,以脑血容量 (CBV) 衡量,是否会导致与年龄和高血压相关的认知功能障碍,重点是执行功能和记忆力。收集了 19 只年龄在 6.4 到 21.6 岁之间的雄性恒河猴的数据。高血压是通过手术缩窄胸主动脉引起的。我们评估了记忆和执行功能任务的表现是否与海马或前额叶皮层的 CBV 相对应。我们在前额叶皮层的灰质而非海马体中发现了高血压持续时间与 CBV 之间的关系。没有发现与高血压程度或年龄的关系。前额叶 CBV 增加与执行功能的更大损害有关,而海马 CBV 与记忆力无关。这些发现表明,高血压或年龄的持续时间而非严重程度是脑微血管系统改变的重要因素,并且执行功能比记忆功能更脆弱。(PsycInfo 数据库记录 (c) 2021 APA,保留所有权利)。
更新日期:2021-07-05
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