Time-restricted feeding and food enriched in polyphenols are strategies to prevent or reduce metabolic disorders. Bean leaves (Phaseolus vulgaris L.) are a recognized source of polyphenolic compounds, whose effects on metabolic pathways are not well studied. We evaluated the combined effects of dietary supplementation with Phaseolus vulgaris leaves (10% w/w) (BL) and a 7-h daytime-restricted feeding protocol (RF) under a hypercaloric diet (high fat + high fructose) (HFFD) on the metabolic parameters related to glucose and lipid handling. Adult male Wistar rats were treated for 8 weeks with standard and HFFD diets with or without BL. The results showed that RF improved metabolic alterations induced by HFFD (e.g., hepatic steatosis, increased triacylglycerols, and serum lipoproteins). Supplementation with BL significantly enhanced this effect and downregulated the mRNA expression of carbohydrate and lipid metabolism genes in the liver. These results indicate that dietary supplementation with BL enhances the benefits elicited by RF.

限时喂养和富含多酚的食物是预防或减少代谢紊乱的策略。豆叶 ( Phaseolus vulgaris L.) 是公认的多酚化合物来源，其对代谢途径的影响尚未得到充分研究。我们评估了在高热量饮食（高脂肪 + 高果糖）（HFFD）下添加菜豆叶（10% w/w）（BL）和 7 小时白天限制喂养方案（RF）的综合影响。与葡萄糖和脂质处理相关的代谢参数。成年雄性 Wistar 大鼠用标准和 HFFD 饮食处理 8 周，有或没有 BL。结果表明，RF 改善了 HFFD 诱导的代谢改变（例如.、肝脂肪变性、甘油三酯和血清脂蛋白增加）。补充BL显着增强了这种作用并下调了肝脏中碳水化合物和脂质代谢基因的mRNA表达。这些结果表明膳食补充剂 BL 增强了 RF 引起的益处。