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Neural mechanisms underlying respiratory regulation within the preBötzinger complex of the rabbit
Respiratory Physiology & Neurobiology ( IF 2.3 ) Pub Date : 2021-07-03 , DOI: 10.1016/j.resp.2021.103736
Elenia Cinelli 1 , Donatella Mutolo 1 , Tito Pantaleo 1 , Fulvia Bongianni 1
Affiliation  

The preBötzinger complex (preBötC) is a medullary area essential for normal breathing and widely recognized as necessary and sufficient to generate the inspiratory phase of respiration. It has been studied mainly in rodents. Here we report the main results of our studies revealing the characteristics of the rabbit preBötC identified by means of neuronal recordings, D,L-homocysteic acid microinjections and histological controls. A crucial role in the respiratory rhythmogenesis within this neural substrate is played by excitatory amino acids, but also GABA and glycine display important contributions. Increases in respiratory frequency are induced by microinjections of neurokinins, somatostatin as well by serotonin (5-HT) through an action on 5-HT1A and 5-HT3 receptors or the disinhibition of a GABAergic circuit. Respiratory depression is observed in response to microinjections of the μ-opioid receptor agonist DAMGO. Our results show similarities and differences with the rodent preBötC and emphasize the importance of comparative studies on the mechanisms underlying respiratory rhythmogenesis in different animal species.



中文翻译:

兔子 preBötzinger 复合体中呼吸调节的神经机制

preBötzinger 复合体 (preBötC) 是正常呼吸所必需的髓质区域,被广泛认为是产生呼吸吸气相的必要和充分条件。它主要在啮齿动物中进行研究。在这里,我们报告了我们研究的主要结果,揭示了通过神经元记录、D,L-同型半胱氨酸显微注射和组织学控制鉴定的兔 preBötC 的特征。兴奋性氨基酸在这种神经基质内的呼吸节律发生中起关键作用,但 GABA 和甘氨酸也表现出重要贡献。显微注射神经激肽、生长抑素以及血清素 (5-HT) 通过作用于 5-HT 1A和 5-HT 3可导致呼吸频率增加受体或 GABA 能回路的去抑制。微量注射 μ-阿片受体激动剂 DAMGO 可观察到呼吸抑制。我们的结果显示了与啮齿动物 preBötC 的异同,并强调了对不同动物物种呼吸节律发生机制进行比较研究的重要性。

更新日期:2021-07-06
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