Abstract

Background

Myocardial bridge (MB) is generally considered as a benign condition, but it may trigger atherosclerosis, especially in the adjacent proximal coronary artery segment. In this study, we aimed to investigate whether the Framingham risk score (FRS) or atherogenic indices are risk factors for coronary atherosclerosis in patients with MB in the left anterior descending coronary artery (LAD).

Methods

We performed a retrospective study evaluating 155 patients who have MB in LAD. The patients were evaluated in two groups according to the presence of atherosclerosis (74 patients in atherosclerotic group vs. 81 patients in non-atherosclerotic group). Baseline characteristics, FRS and atherogenic indices were reviewed between groups. Significant independent risk factors for coronary atherosclerosis were investigated by logistic regression analysis.

Results

Patients in atherosclerotic group were significantly older (58.15 ± 10.04 vs. 50.22 ± 9.27 years, p < .001) and 74.3% of the patients were male. While the mean FRS in the atherosclerotic group was 21.20 ± 8.81, it was 12.79 ± 8.61 in the non-atherosclerotic group (p < .001). Among the atherogenic indices, only LDL-c/HDL-c ratio was significantly higher in the atherosclerotic group (3.49 ± 1.2 vs. 3.11 ± 0.98, p:.033). Multivariable analysis showed that age (OR: 1.08, 95% CI 1.03–1.13, p < .001) and FRS (OR: 1.06, 95% CI 1.01–1.11, p:.012) were independently associated with the presence of atherosclerotic lesion.

Conclusions

FRS is an easily applicable predictor in clinical practice that indicates the presence of coronary atherosclerosis in patients with MB in LAD.

中文翻译：

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Framingham 风险评分和动脉粥样硬化指数作为左前降支心肌桥患者动脉粥样硬化预测指标的比较

摘要

背景

心肌桥 (MB) 通常被认为是一种良性疾病，但它可能会引发动脉粥样硬化，尤其是在邻近的冠状动脉近端节段。在这项研究中，我们旨在调查弗雷明汉风险评分（FRS）或动脉粥样硬化指数是否是左冠状动脉前降支（LAD）MB患者冠状动脉粥样硬化的危险因素。

方法

我们进行了一项回顾性研究，评估了 155 名 LAD 中的 MB 患者。根据是否存在动脉粥样硬化对患者进行两组评估（动脉粥样硬化组 74 例患者与非动脉粥样硬化组 81 例患者）。对组间的基线特征、FRS 和动脉粥样硬化指数进行了回顾。通过逻辑回归分析研究冠状动脉粥样硬化的显着独立危险因素。

结果

动脉粥样硬化组的患者年龄显着增加（58.15 ± 10.04  vs. 50.22 ± 9.27 岁，p  < .001），74.3% 的患者为男性。动脉粥样硬化组的平均 FRS 为 21.20 ± 8.81，而非动脉粥样硬化组为 12.79 ± 8.61 ( p  < .001)。在动脉粥样硬化指数中，只有 LDL-c/HDL-c 比率在动脉粥样硬化组中显着升高（3.49 ± 1.2 vs. 3.11 ± 0.98，p :.033）。多变量分析显示年龄（OR：1.08，95% CI 1.03-1.13，p  < .001）和 FRS（OR：1.06，95% CI 1.01-1.11，p：0.012）与动脉粥样硬化病变的存在独立相关.

结论

FRS 是临床实践中易于应用的预测指标，它表明 LAD 中 MB 患者存在冠状动脉粥样硬化。