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Cytotoxicity and effects of curcumin and cinnamaldehyde hybrids on biofilms of oral pathogens
Biofouling ( IF 2.7 ) Pub Date : 2021-07-01 , DOI: 10.1080/08927014.2021.1942859
Vanessa Rodrigues Dos Santos 1 , Karina Sampaio Caiaffa 1 , Warlley Campos de Oliveira 1 , Jesse Augusto Pereira 1 , Gabriel Flores Abuna 2 , Carlos Roberto Polaquini 3 , Luís Octávio Regasini 3 , Aimée Maria Guiotti 4 , Cristiane Duque 1
Affiliation  

Abstract

The objective of the study was to evaluate the cytotoxicity and effect of curcumin-cinnamaldehyde hybrids (CCHs) on the biofilm of oral pathogens. Of the 18 hybrids tested, nine had an inhibitory effect on at least one of the bacterial species tested, with minimal inhibitory and bactericidal concentrations ranging from 9 to 625 μg ml−1. CCH 7 promoted a potent inhibitory effect against all the bacterial species tested and better compatibility than chlorhexidine (CHX). CCH 7 also presented a similar or improved effect over that of CHX, causing a reduction in bacterial metabolism and viability in single and dual-species biofilms. CCH 7 reduced by 86% and 34% the viability of multispecies biofilms formed by collection and clinical strains. It can be concluded that CCH 7 was cytocompatible at the minimal inhibitory concentration, presented anti-biofilm action against oral pathogens, and could act as an antimicrobial agent for application in endodontics.



中文翻译:

姜黄素和肉桂醛杂化物对口腔病原体生物膜的细胞毒性和影响

摘要

该研究的目的是评估姜黄素-肉桂醛杂交体 (CCH) 对口腔病原体生物膜的细胞毒性和影响。在测试的 18 个杂交种中,有 9 个对至少一种测试的细菌物种具有抑制作用,最小抑制和杀菌浓度范围为 9 至 625 μg ml -1. CCH 7 促进对所有测试的细菌物种的有效抑制作用,并且比氯己定 (CHX) 具有更好的相容性。CCH 7 还表现出与 CHX 相似或改进的效果,导致单物种和双物种生物膜中细菌代谢和活力的降低。CCH 7 将收集和临床菌株形成的多物种生物膜的活力降低了 86% 和 34%。可以得出结论,CCH 7 在最小抑制浓度下具有细胞相容性,对口腔病原体具有抗生物膜作用,可作为抗菌剂应用于牙髓病学。

更新日期:2021-08-13
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