Mindfulness ( IF 3.801 ) Pub Date : 2021-07-02 , DOI: 10.1007/s12671-021-01667-9 Minji Bang 1 , Borah Kim 1 , Kang Soo Lee 1 , Tai Kiu Choi 1 , Sang-Hyuk Lee 1
Objectives
Mindfulness-based cognitive therapy (MBCT) as an adjunctive to pharmacotherapy (PT) has been suggested as a good treatment option for panic disorder (PD). However, its long-term effectiveness in generating positive treatment outcomes remains to be established. We assessed the long lasting effectiveness of adjunctive MBCT up to 5 years and the influence of genetic variations on treatment outcomes in patients with PD.
Methods
A total of 109 participants who received adjunctive MBCT to PT (MBCT + PT) and 109 age- and sex-matched patient controls (PT-alone) were followed up for relapse or aggravation of PD up to 5 years. The serotonin transporter gene-linked polymorphic region (5-HTTLPR), catechol-O-methyltransferase, and brain-derived neurotrophic factor polymorphisms were analyzed at baseline.
Results
Adjunctive MBCT significantly reduced the risk for relapse or aggravation of PD for up to 5 years. 5-HTTLPR polymorphism also had a significant positive effect on the long term outcome of PD; however, there was no therapygenetic effect on the benefits of adjunctive MBCT.
Conclusions
This 5-year follow-up study demonstrated the enduring therapeutic effects of MBCT adjunctive to PD for improving long-term treatment outcome in patients with PD. Furthermore, 5-HTTLPR polymorphism may be a moderator of treatment experiences that further boost treatment success. Future investigations are warranted to establish the clinical application of MBCT and the need for personalized treatment strategies to maintain positive outcomes in patients with PD.
中文翻译:
基于正念的认知疗法对恐慌症阳性临床结果的有效性:一项为期 5 年的纵向研究
目标
正念认知疗法 (MBCT) 作为药物疗法 (PT) 的辅助手段已被建议作为恐慌症 (PD) 的良好治疗选择。然而,其在产生积极治疗结果方面的长期有效性仍有待确定。我们评估了辅助 MBCT 长达 5 年的长期有效性以及遗传变异对 PD 患者治疗结果的影响。
方法
共有 109 名接受了 PT 辅助 MBCT(MBCT + PT)的参与者和 109 名年龄和性别匹配的患者对照(单独 PT)接受了长达 5 年的 PD 复发或加重随访。基线时分析血清素转运蛋白基因相关多态性区域 ( 5-HTTLPR )、儿茶酚-O-甲基转移酶和脑源性神经营养因子多态性。
结果
辅助 MBCT 可显着降低 PD 复发或加重的风险长达 5 年。5-HTTLPR多态性对 PD 的长期预后也有显着的积极影响;然而,对辅助性 MBCT 的益处没有治疗遗传效应。
结论
这项为期 5 年的随访研究证明了 MBCT 辅助 PD 的持久治疗效果,可改善 PD 患者的长期治疗结果。此外,5-HTTLPR多态性可能是治疗体验的调节剂,可进一步提高治疗成功率。未来的研究有必要确定 MBCT 的临床应用以及个性化治疗策略的必要性,以保持 PD 患者的积极结果。