To reduce the exposure of the French West Indies population to the organochlorine insecticide chlordecone (Kepone; CLD), the contamination of currently consumed foodstuffs must be reduced. Depuration of contaminated animals before slaughter could be a strategy to obtain safe animal products. The aim of this study was to characterize and quantify CLD elimination in contaminated ewes during depuration process. Experiments A and B consisted in a single intravenous (i.v.) administration of CLD (n = 5) and CLDOH (chlordecol; n = 3) followed by a 84-d and 3-d depuration period respectively with collection of blood, faeces and urine samples. After CLD administration, CLD and conjugated-CLDOH (CLDOH-C) were quantified in serum and urine and CLD and CLDOH were quantified in faeces. Based on calculations of faecal, urinary and body clearances of CLD and CLDOH-C, faeces appeared as the major route of CLD excretion with 86 % of the CLD administered dose eliminated in faeces, either as CLD (51 %) or as CLDOH (35 %).

为了减少法属西印度群岛人口对有机氯杀虫剂十氯酮（Kepone；CLD）的暴露，必须减少目前消费的食品的污染。在屠宰前净化受污染的动物可能是获得安全动物产品的一种策略。本研究的目的是表征和量化净化过程中受污染母羊的 CLD 消除。实验 A 和 B 包括单次静脉注射 ( iv) 施用 CLD (n = 5) 和 CLDOH (chlordecol; n = 3)，然后分别进行 84 天和 3 天的净化期，收集血液、粪便和尿液样本。在 CLD 给药后，CLD 和共轭 CLDOH (CLDOH-C) 在血清和尿液中被量化，CLD 和 CLDOH 在粪便中被量化。根据对 CLD 和 CLDOH-C 的粪便、尿和身体清除率的计算，粪便是 CLD 排泄的主要途径，86% 的 CLD 给药剂量以 CLD（51%）或 CLDOH（35 %）。