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Does chronic inflammation cause acute inflammation to spiral into hyper-inflammation in a manner modulated by diet and the gut microbiome, in severe Covid-19?
BioEssays ( IF 4 ) Pub Date : 2021-07-02 , DOI: 10.1002/bies.202000211
Manni Luthra-Guptasarma 1 , Purnananda Guptasarma 2
Affiliation  

We propose that hyper-inflammation (HYPi) is a ‘‘runaway’’ consequence of acute inflammation (ACUi) that arises more easily (and also abates less easily) in those who host a pre-existing chronic inflammation (CHRi), because (i) most factors involved in generating an ACUi to limit viral proliferation are already present when there is an underlying CHRi, and also because (ii) anti-inflammatory (AI) mechanisms for the abatement of ACUi (following containment of viral proliferation) are suppressed and desensitized where there is an underlying CHRi, with this causing the ACUi to spiral into a HYPi. Stress, pollution, diet, and gut microbiomes (alterable in weeks through dietary changes) have an intimate and bidirectional cause-effect relationship with CHRi. We propose that avoidance of CHRi-promoting foods and adoption of CHRi-suppressing foods could reduce susceptibility to HYPi, in Covid-19 and in other viral diseases, such as influenza, which are characterized by episodic and unpredictable HYPi.

中文翻译:

在严重的 Covid-19 中,慢性炎症是否会导致急性炎症以一种受饮食和肠道微生物群调节的方式演变为过度炎症?

我们提出,过度炎症 (HYPi) 是急性炎症 (ACUi) 的“失控”后果,在患有预先存在的慢性炎症 (CHRi) 的人中更容易出现(并且也不太容易减轻),因为( i) 当存在潜在的 CHRi 时,大多数与产生 ACUi 以限制病毒增殖有关的因素已经存在,并且还因为 (ii) 用于减少 ACUi(在遏制病毒增殖后)的抗炎 (AI) 机制被抑制并且在有潜在 CHRi 的地方脱敏,这导致 ACUi 螺旋式变成 HYPi。压力、污染、饮食和肠道微生物群(通过饮食变化在数周内改变)与 CHRi 具有密切的双向因果关系。
更新日期:2021-08-27
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