A high yielding, cost-effective, and regioselective methodology for the gram-scale synthesis of 6-O-ascorbyl esters has been developed by the esterification of l-ascorbic acid with a variety of saturated long-chain fatty acids in the presence conc. H₂SO₄. A renewable food-grade solvent, p-cymene, was efficiently used in the process to affect the product separation from the reaction mixture while the physical methods, e.g., cooling and centrifugation, were applied for product isolation in good yields (70–82%) and purity (> 99%). The methodology was scaled up for the production of 6-O-ascorbyl palmitate (45 g) in 80% yields and > 99% purity. A direct application of the developed method on low-value fats and oils resulted in the synthesis of a mixture of 6-O-ascorbyl esters for use as antioxidants in food products.

甲高产，高性价比的，选择性和区域选择性方法为6-的克级合成ö抗坏血酸基酯已经通过酯化开发升抗坏血酸与多种在存在浓饱和长链脂肪酸。H ₂ SO ₄。在该过程中有效地使用了一种可再生的食品级溶剂对伞花烃，以影响反应混合物中的产物分离，而物理方法，例如冷却和离心，用于以良好的产率（70-82%）分离产物。 ) 和纯度 (> 99%)。该方法用于生产 6- O-抗坏血酸棕榈酸酯 (45 g)，产率 80%，纯度 > 99%。将开发的方法直接应用于低价值脂肪和油，导致合成 6- O-抗坏血酸酯的混合物，用作食品中的抗氧化剂。