MYC is a transcription factor controlling growth and nutrient metabolism. Luo et al. now link intestinal expression of MYC to impairments in glucose, lipid and body-weight homeostasis by uncovering novel roles of MYC in regulating the glucagon-like peptide GLP1 and the ceramide-biosynthesis regulator CERS4. Myc deletion in the intestinal epithelium prevents or reverses diet-induced obesity and hepatic steatosis in mice. Critically, people with obesity display elevated MYC and CERS4 expression in the ileum, thus further supporting the clinical relevance of these findings.

中文翻译：

---

去除Myc以减少神经酰胺

MYC 是一种控制生长和营养代谢的转录因子。罗等人。现在，通过揭示 MYC 在调节胰高血糖素样肽 GLP1 和神经酰胺生物合成调节剂 CERS4 中的新作用，将 MYC 的肠道表达与葡萄糖、脂质和体重稳态的损害联系起来。肠道上皮中的 Myc 缺失可预防或逆转小鼠饮食引起的肥胖和肝脂肪变性。至关重要的是，肥胖人群在回肠中的 MYC 和 CERS4 表达升高，因此进一步支持了这些发现的临床相关性。