当前位置: X-MOL 学术Mini-Rev. Med. Chem. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Therapeutic Properties of Several Chemical Compounds of Salvia officinalis L. in Alzheimer’s Disease
Mini-Reviews in Medicinal Chemistry ( IF 3.8 ) Pub Date : 2021-06-30 , DOI: 10.2174/1389557521999201230200209
Georgiana Uță 1 , Denisa Ștefania Manolescu 1 , Speranța Avram 1
Affiliation  

Background: Currently, the pharmacological management of Alzheimer's disease is based on several chemical structures, represented by acetylcholinesterase and N-methyl-D-aspartate (NMDA) receptor ligands, with still unclear molecular mechanisms and severe side effects. For this reason, a challenge for Alzheimer's disease treatment remains to identify new drugs with reduced side effects. Recently, the natural compounds, particularly, certain chemical compounds identified in the essential oil of peppermint, sage, grapes, sea buckthorn, have increased interest as possible therapeutics.

Objectives: In this paper, we have summarized data from the recent literature on several chemical compounds extracted from Salvia officinalis L., with therapeutic potential in Alzheimer's disease.

Methods: In addition to the wide range of experimental methods performed in vivo and in vitro, we also presented some in silico studies of medicinal compounds.

Results: Through this mini-review, we presented the latest information regarding the therapeutic characteristics of natural compounds isolated from Salvia officinalis L. in Alzheimer's disease.

Conclusion: Thus, based on the information presented, we can say that phytotherapy is a reliable therapeutic method in a neurodegenerative disease.



中文翻译:

丹参的几种化合物在阿尔茨海默病中的治疗特性

背景:目前,阿尔茨海默病的药理学管理基于几种化学结构,以乙酰胆碱酯酶和 N-甲基-D-天冬氨酸 (NMDA) 受体配体为代表,分子机制尚不清楚,副作用严重。出于这个原因,阿尔茨海默病治疗的挑战仍然是确定副作用减少的新药。最近,天然化合物,特别是在薄荷、鼠尾草、葡萄、沙棘精油中鉴定出的某些化合物,作为可能的治疗剂越来越受到关注。

目的:在本文中,我们总结了近期文献中关于从丹参提取的几种化合物的数据,这些化合物具有治疗阿尔茨海默病的潜力。

方法:除了在体内和体外进行的广泛的实验方法外,我们还介绍了一些药物化合物的计算机研究。

结果:通过这个小型综述,我们提供了关于从 Salvia officinalis L. 中分离的天然化合物在阿尔茨海默病中的治疗特性的最新信息。

结论:因此,根据所提供的信息,我们可以说植物疗法是一种可靠的神经退行性疾病治疗方法。

更新日期:2021-07-02
down
wechat
bug