Memory remains an obligatory regime of the human brain, and impaired memory causes serious obstacles in our everyday life. Alzheimer’s disease (AD) is one such neurodegenerative disease which mostly affects the elderly population, above the age of 60; marked by cognitive impairment of memory. Besides the known targets of AD against the several etiologies known to date, the zone of epigenetics has recently evolved as an ingenious field in AD. Epigenetic modifications do not affect DNA sequence but only long-term gene expression. Considering the complex multifactorial nature of AD, we herein discuss the various epigenetic targets which might give rise to potential therapeutic approaches. We reviewed the possible epigenetic targets for AD-like HDAC, Sirtuins, glial cells, miRNA and epigenetic modifications like DNA methylation. A deeper insight into these target areas can surely evolve AD diagnosis and therapeutics.

记忆仍然是人类大脑的强制性制度，而受损的记忆会给我们的日常生活带来严重的障碍。阿尔茨海默病 (AD) 就是这样一种神经退行性疾病，主要影响 60 岁以上的老年人群；以记忆力的认知障碍为特征。除了针对迄今为止已知的几种病因的 AD 的已知靶点之外，表观遗传学区域最近已经发展成为 AD 中的一个巧妙领域。表观遗传修饰不影响 DNA 序列，只影响长期基因表达。考虑到 AD 复杂的多因素性质，我们在此讨论可能产生潜在治疗方法的各种表观遗传靶点。我们回顾了 AD 样 HDAC、Sirtuins、神经胶质细胞、miRNA 和表观遗传修饰（如 DNA 甲基化）的可能表观遗传靶点。