ABSTRACT

Objective: Several systematic reviews (SRs) have assessed the diagnostic accuracy of microRNAs (miRNAs) for NSCLC, and this overview aimed to assess the relationship between diagnostic accuracy of miRNAs for NSCLC and number of microRNAs combinations. Methods: Embase.com, PubMed, the Cochrane Library, and Web of Science were searched. The PRISMA-DTA was used for reporting quality evaluation. Meta-analysis was conducted to assess the pooled diagnostic accuracy of different miRNAs combinations, and subgroup analyses were performed based on the source of miRNA. Results: Fourteen SRs with 91 original studies were included. Three SRs had minimal reporting flaws, and 11 SRs had medium flaws. The pooled sensitivity and specificity were 0.76 and 0.80 for single miRNA, 0.80 and 0.81 for two miRNAs combined, 0.82 and 0.88 for three miRNAs combined, 0.88 and 0.92 for four miRNAs combined, 0.87 and 0.87 for five miRNAs combined, and 0.87 and 0.89 for six or more miRNAs combined. And miR-21 was mostly appeared. Subgroup analyses suggested that the serum-derived miRNA had the relatively best diagnostic value compared to other sources. Conclusions: Future studies should explore specific and serum-derived miRNAs in NSCLC and combine them to improve the diagnosis accuracy of NSCLC, which had great significance in economic efficiency.

摘要

目的：一些系统评价 (SR) 评估了 microRNAs (miRNAs) 对 NSCLC 的诊断准确性，本综述旨在评估 miRNAs 对 NSCLC 的诊断准确性与 microRNAs 组合数量之间的关系。方法：检索 Embase.com、PubMed、Cochrane 图书馆和 Web of Science。PRISMA-DTA 用于报告质量评估。进行 Meta 分析以评估不同 miRNA 组合的汇总诊断准确性，并根据 miRNA 的来源进行亚组分析。结果：包含 14 个 SR，包含 91 项原始研究。三个 SR 的报告缺陷最小，11 个 SR 的缺陷中等。单一 miRNA 的汇总敏感性和特异性分别为 0.76 和 0.80，两种 miRNA 组合的综合敏感性和特异性为 0.80 和 0.81，三种 miRNA 组合的综合敏感性和特异性分别为 0.82 和 0.88，四种 miRNA 组合的 0.88 和 0.92，五种 miRNA 组合的 0.87 和 0.87，以及 0.87 和 0.89六个或更多的 miRNA 组合。且以miR-21居多。亚组分析表明，与其他来源相比，血清来源的 miRNA 具有相对最佳的诊断价值。结论：未来的研究应探索NSCLC中特异性和血清来源的miRNA，并将它们结合起来，以提高NSCLC的诊断准确性，这对经济效益具有重要意义。