Continuous expression of reprogramming factors induces and maintains mouse pluripotency without specific growth factors and signaling inhibitors,Cell Proliferation

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Continuous expression of reprogramming factors induces and maintains mouse pluripotency without specific growth factors and signaling inhibitors
Cell Proliferation ( IF 8.5 ) Pub Date : 2021-07-01 , DOI: 10.1111/cpr.13090
Yihuan Mao _{1,

2,

3} , Libin Wang _{1,

2,

4} , Bei Zhong _{1,

5} , Ning Yang _{1,

2,

3} , Zhikun Li _{1,

2,

4} , Tongtong Cui _{1,

2,

4} , Guihai Feng _{1,

2,

4} , Wei Li _{1,

2,

3,

4} , Ying Zhang _{1,

2,

4} , Qi Zhou _{1,

2,

3,

4}

Affiliation

Derivation and maintenance of pluripotent stem cells (PSCs) generally require optimized and complex culture media, which hinders the derivation of PSCs from various species. Expression of Oct4, Sox2, Klf4, and c-Myc (OSKM) can reprogram somatic cells into induced PSCs (iPSCs), even for species possessing no optimal culture condition. Herein, we explored whether expression of OSKM could induce and maintain pluripotency without PSC-specific growth factors and signaling inhibitors.

中文翻译：

重编程因子的连续表达诱导并维持小鼠的多能性，无需特定的生长因子和信号抑制剂

多能干细胞 (PSC) 的衍生和维持通常需要优化和复杂的培养基，这阻碍了从各种物种衍生 PSC。Oct4、Sox2、Klf4 和 c-Myc (OSKM) 的表达可以将体细胞重新编程为诱导 PSC (iPSC)，即使对于没有最佳培养条件的物种也是如此。在此，我们探讨了 OSKM 的表达是否可以在没有 PSC 特异性生长因子和信号抑制剂的情况下诱导和维持多能性。

更新日期：2021-08-09

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