An efficient Suzuki-Miyaura cross-coupling reaction of ortho-phenoxy-substituted aromatic amides with aryl boronates is described. The use of LiO^tBu is crucial for the success of the reaction. An amidate anion, which is formed through deprotonation of the amide NH bond by LiO^tBu, functions as a directing group to activate a C−O bond.

中文翻译：

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涉及 C-O 键活化的镍催化 Suzuki-Miyaura 交叉偶联

描述了邻苯氧基取代的芳香酰胺与芳基硼酸酯的有效Suzuki-Miyaura交叉偶联反应。LiO ^t Bu的使用对于反应的成功至关重要。通过 LiO ^t Bu对酰胺 NH 键的去质子化形成的酰胺阴离子作为导向基团来激活 CO 键。