Protein synthesis regulation constitutes a key node in directing decisions between hematopoietic stemness and differentiation. In this issue of Cell Stem Cell, Lv et al. (2021) describe a mechanism by which HSCs fine-tune translation rates by controlling 60S and 40S ribosomal subunit joining through targeted degradation of ZNF622 in response to stress.

中文翻译：

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释放造血干细胞蛋白质合成的刹车

蛋白质合成调控是指导造血干性和分化之间决策的关键节点。在本期Cell Stem Cell 中，Lv 等人。(2021) 描述了一种机制，通过该机制，HSC 通过控制 60S 和 40S 核糖体亚基连接来响应压力，ZNF622 有针对性地降解。