Joint replacement surgery is one of the orthopedic surgeries with high successful rates; however, wear debris generated from prostheses can ultimately lead to periprosthetic osteolysis and failure of the implant. The implant-derived particulate debris such as ultrahigh molecular weight polyethylene (UHMWPE) can initiate the local immune response and recruit monocytic cells to phagocytose particles for generating reactive oxygen species (ROS). ROS induces osteoclastogenesis and macrophages to secrete cytokines which ultimately promote the development of osteolysis. In this work, we develop the few-layered Nb₂C (FNC) as an antioxidant which possesses the feature of decreasing the production of cytokines and inhibiting osteoclastogenesis by its ROS adsorption. Moreover, local injection of FNC attenuates the UHMWPE-induced osteolysis in a mouse calvarial model. In sum, our results suggest that FNC can be used for treating osteolytic bone disease caused by excessive osteoclastogenesis.

关节置换手术是成功率较高的骨科手术之一；然而，假体产生的磨损碎屑最终会导致假体周围骨质溶解和植入物失效。植入物衍生的颗粒碎片如超高分子量聚乙烯 (UHMWPE) 可以启动局部免疫反应并招募单核细胞吞噬颗粒以产生活性氧 (ROS)。ROS 诱导破骨细胞生成和巨噬细胞分泌细胞因子，最终促进骨溶解的发展。在这项工作中，我们开发了少层 Nb ₂C (FNC) 作为一种抗氧化剂，具有通过其 ROS 吸附减少细胞因子的产生和抑制破骨细胞生成的特性。此外，FNC 的局部注射减弱了小鼠颅骨模型中 UHMWPE 诱导的骨溶解。总之，我们的结果表明 FNC 可用于治疗由过度破骨细胞生成引起的溶骨性骨病。