The field of nuclear medicine is rapidly evolving due to the high demand of radiopharmaceuticals for diagnostic and therapeutic applications. The availability of a vast array of radioisotopes, improvement in radiolabeling strategies, and advancements in detection systems have also contributed to the progress in this field. Radiopharmaceuticals are mainly classified based on their application as diagnostic or therapeutic radiopharmaceuticals. These are available either as ready to use preparations or prepared at hospital radiopharmacy either using automated synthesis modules or by using freezedried cold kit formulations. Availability of freeze-dried cold kits for preparation of varied radiopharmaceuticals for targeting various organs and tumors played an essential role in the extensive use of ^99mTc radiopharmaceuticals for diagnostic imaging by single-photon emission computed tomography (SPECT) imaging. Cold kits are especially suitable for the preparation of radiopharmaceuticals labeled with isotopes like ¹⁷⁷Lu with relatively long half-life or radionuclides produced by radioisotope generators. A simplified procedure for the preparation of positron emission tomography (PET) radiopharmaceuticals is also desired to achieve images with higher resolution and sensitivity offered by PET. Robust kit formulations will simplify the preparation of PET radiopharmaceuticals and will contribute to extensive applications of positron emitters such as ⁶⁸Ga. Several therapeutic radiopharmaceuticals are also being made using cold kits of the ligands. This review provides an update on diagnostic and therapeutic radiopharmaceuticals prepared using cold kits.

由于诊断和治疗应用对放射性药物的高需求，核医学领域正在迅速发展。大量放射性同位素的可用性、放射性标记策略的改进以及检测系统的进步也促进了该领域的进步。放射性药物主要根据其应用分类为诊断性或治疗性放射性药物。这些可以作为即用型制剂获得，也可以在医院放射性药物学中使用自动合成模块或使用冷冻干燥的冷试剂盒制剂制备。用于制备针对各种器官和肿瘤的各种放射性药物的冻干冷试剂盒的可用性在^99m的广泛使用中发挥了重要作用用于通过单光子发射计算机断层扫描 (SPECT) 成像进行诊断成像的 Tc 放射性药物。冷试剂盒特别适用于制备同位素标记的放射性药物，如半衰期较长的¹⁷⁷ Lu 或放射性同位素发生器产生的放射性核素。还需要一种用于制备正电子发射断层扫描 (PET) 放射性药物的简化程序，以实现 PET 提供的具有更高分辨率和灵敏度的图像。强大的试剂盒配方将简化 PET 放射性药物的制备，并将有助于正电子发射体的广泛应用，例如⁶⁸Ga. 也正在使用配体的冷试剂盒制造几种治疗性放射性药物。这篇综述提供了关于使用冷试剂盒制备的诊断和治疗放射性药物的最新情况。