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Halogen Bond-Catalyzed Friedel-Crafts Alkylation of Indole with Ketones and Aldehydes for the Synthesis of Symmetrical 3,3’-diindolylmethanes Using Simple Halogen Donor Catalyst
Letters in Organic Chemistry ( IF 0.8 ) Pub Date : 2021-07-31 , DOI: 10.2174/1570178617999201012181016
Xiao-Yu Zhou 1 , Xia Chen 1
Affiliation  

The Friedel-Crafts alkylation of indole with ketones and aldehydes had been developed to prepare 3,3’-diindolylmethanes using iodine or NCS as catalysts. Two mild and efficient catalysis systems were provided for the activation of carbonyl compounds and indoles. The reaction proceeded smoothly in ethanol to produce the corresponding products with good to excellent yields. Furtherly, the mechanism was speculated.



中文翻译:

使用简单的卤素供体催化剂合成对称 3,3'-二吲哚基甲烷的吲哚与酮和醛的卤素键催化 Friedel-Crafts 烷基化

吲哚与酮和醛的 Friedel-Crafts 烷基化反应已被开发以使用碘或 NCS 作为催化剂制备 3,3'-二吲哚基甲烷。为羰基化合物和吲哚的活化提供了两种温和高效的催化体系。反应在乙醇中顺利进行,得到相应的产物,收率良好至极好。此外,推测其机制。

更新日期:2021-07-01
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