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Facile Synthesis of (E)-5-Styrylpyrimidines via Wittig Reaction Using Sodium Tripolyphosphate in Water
Letters in Organic Chemistry ( IF 0.8 ) Pub Date : 2021-07-31 , DOI: 10.2174/1570178617999201012181526 Anilkumar S. Patel 1 , Sahaj A. Gandhi 2 , Rajesh D. Modh 3 , Urmila H. Patel 4 , Yogesh T. Naliapara 5 , Naval P. Kapuriya 6
中文翻译:
使用三聚磷酸钠在水中通过 Wittig 反应轻松合成 (E)-5-苯乙烯基嘧啶
更新日期:2021-07-01
Letters in Organic Chemistry ( IF 0.8 ) Pub Date : 2021-07-31 , DOI: 10.2174/1570178617999201012181526 Anilkumar S. Patel 1 , Sahaj A. Gandhi 2 , Rajesh D. Modh 3 , Urmila H. Patel 4 , Yogesh T. Naliapara 5 , Naval P. Kapuriya 6
Affiliation
An inexpensive and eco-friendly Wittig olefination protocol has been developed to prepare novel (E)-5-styrylpyrimidines. The reaction of pyrimidine phosphonium ylide with different aryl/heteroaryl aldehydes underwent smoothly in the presence of sodium tripolyphosphate (STPP) in aqueous condition giving (E)-5-styrylpyrimidines (10a-t) in very high yields (77-96 %).
中文翻译:
使用三聚磷酸钠在水中通过 Wittig 反应轻松合成 (E)-5-苯乙烯基嘧啶
已开发出一种廉价且环保的 Wittig 烯化方案来制备新型 (E)-5-苯乙烯基嘧啶。嘧啶鏻叶立德与不同芳基/杂芳基醛的反应在三聚磷酸钠 (STPP) 存在下在水性条件下顺利进行,以非常高的产率 (77-96%) 得到 (E)-5-苯乙烯基嘧啶 (10a-t)。