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A multi-cellular molecular signaling and functional network map of C–C motif chemokine ligand 18 (CCL18): a chemokine with immunosuppressive and pro-tumor functions
Journal of Cell Communication and Signaling ( IF 4.1 ) Pub Date : 2021-07-01 , DOI: 10.1007/s12079-021-00633-3
Anjana Aravind 1 , Akhina Palollathil 1 , D A B Rex 1 , Kenkere M Kiran Kumar 2 , Manavalan Vijayakumar 2 , Rohan Shetty 2 , Jalaluddin Akbar Kandel Codi 2 , Thottethodi Subrahmanya Keshava Prasad 1 , Rajesh Raju 1
Affiliation  

The C–C Motif Chemokine Ligand 18 (CCL18) is a beta-chemokine sub-family member with immunomodulatory functions in primates. CCL18-dependent migration and epithelial-to-mesenchymal transition of oral squamous cell carcinoma, squamous cell carcinoma of head and neck, breast cancer, hepatocellular carcinoma, non-small cell lung carcinoma, ovarian cancer, pancreatic ductal carcinoma and bladder cancer cells are well-established. In the tumor niche, tumor-associated macrophages produce CCL18 and its overexpression is correlated with reduced patient survival in multiple cancers. Although multiple receptors including C–C chemokine receptor type 3 (CCR3), type 6 (CCR6), type 8 (CCR8) and G-protein coupled estrogen receptor (GPER1) are reported for CCL18, the Phosphatidylinositol Transfer Protein, Membrane-Associated 3 (PITPNM3) receptor is currently considered as its predominant receptor. Characterization of the molecular events and check points associated with the immunosuppressive and cancer progression support functions induced by CCL18 for their potential towards therapeutic applications is an area of active research. Hence, in this study, we assembled 917 signaling events reported to be induced by CCL18 through their studied receptors in diverse cell types as an integrated knowledgebase for reference, data integration and gene-set enrichment analysis of global transcriptomic and/or proteomics datasets.



中文翻译:

C-C基序趋化因子配体18(CCL18)的多细胞分子信号和功能网络图:具有免疫抑制和促肿瘤功能的趋化因子

C–C 基序趋化因子配体 18 (CCL18) 是一种在灵长类动物中具有免疫调节功能的 β-趋化因子亚家族成员。口腔鳞状细胞癌、头颈部鳞状细胞癌、乳腺癌、肝细胞癌、非小细胞肺癌、卵巢癌、胰腺导管癌和膀胱癌细胞的 CCL18 依赖性迁移和上皮间质转化良好-已确立的。在肿瘤生态位中,肿瘤相关巨噬细胞产生 CCL18,其过度表达与多种癌症患者存活率降低相关。尽管据报道有多种受体,包括 C-C 趋化因子受体 3 型 (CCR3)、6 型 (CCR6)、8 型 (CCR8) 和 G 蛋白偶联雌激素受体 (GPER1),用于 CCL18、磷脂酰肌醇转移蛋白、膜相关 3 (PITPNM3) 受体目前被认为是其主要受体。与 CCL18 诱导的免疫抑制和癌症进展支持功能相关的分子事件和检查点的表征及其在治疗应用方面的潜力是一个活跃的研究领域。因此,在本研究中,我们组装了 917 个据报道由 CCL18 通过其在不同细胞类型中研究的受体诱导的信号事件,作为全球转录组学和/或蛋白质组学数据集的参考、数据集成和基因集富集分析的综合知识库。与 CCL18 诱导的免疫抑制和癌症进展支持功能相关的分子事件和检查点的表征及其在治疗应用方面的潜力是一个活跃的研究领域。因此,在本研究中,我们组装了 917 个据报道由 CCL18 通过其在不同细胞类型中研究的受体诱导的信号事件,作为全球转录组学和/或蛋白质组学数据集的参考、数据集成和基因集富集分析的综合知识库。与 CCL18 诱导的免疫抑制和癌症进展支持功能相关的分子事件和检查点的表征及其在治疗应用方面的潜力是一个活跃的研究领域。因此,在本研究中,我们组装了 917 个据报道由 CCL18 通过其在不同细胞类型中研究的受体诱导的信号事件,作为全球转录组学和/或蛋白质组学数据集的参考、数据集成和基因集富集分析的综合知识库。

更新日期:2021-07-01
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