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Suction Cups-Inspired Adhesive Patch with Tailorable Patterns for Versatile Wound Healing
Advanced Science ( IF 15.1 ) Pub Date : 2021-07-01 , DOI: 10.1002/advs.202100201
Rongkang Huang 1 , Xiaoxuan Zhang 2, 3 , Wenzhao Li 4 , Luoran Shang 5 , Hui Wang 1 , Yuanjin Zhao 2, 3
Affiliation  

Medical patches play an important role in wound healing because of their tissue conformality, drug release capacity, and convenient operation. Great efforts have been devoted to developing new-generation patches with distinctive features promoting wound healing. Here, inspired by the structure of octopus suction cups and the component of natural tissue, a biocompatible wound patch with selective adhesiveness and individualized design using a combined strategy of template-replication and mask-guided lithography is presented. Such patches are based on Ecoflex film with suction-cup-mimicking microstructures to adhere to normal skin and with biocompatible gelatin methacryloyl (GelMA) hydrogel to contact wounded areas. An ultraviolet mask with a tailorable pattern is employed to shape the GelMA hydrogel into customized geometry replicating individual wound areas, and thus both adhesion and antiadhesion properties are integrated into the same patch. In addition, vascular endothelial growth factor is loaded to accelerate the healing process. Based on these advantages, the authors demonstrate that the present patches not only adhere to different skin surfaces, but also promote the treatment of a rat cutaneous wound model. Thus, it is believed that this versatile patch can break through the limitation of traditional patches and be ideal candidates for wound healing and related biomedical applications.

中文翻译:

受吸盘启发的贴片,具有可定制的图案,可用于多种伤口愈合

医用贴剂因其组织适形性、药物释放能力和操作方便等特点,在伤口愈合中发挥着重要作用。人们致力于开发具有独特促进伤口愈合功能的新一代贴剂。在这里,受章鱼吸盘结构和自然组织成分的启发,采用模板复制和掩模引导光刻的组合策略,提出了一种具有选择性粘附性和个性化设计的生物相容性伤口贴片。此类贴片基于 Ecoflex 薄膜,具有模仿吸盘的微结构,可粘附到正常皮肤上,并采用生物相容性明胶甲基丙烯酰 (GelMA) 水凝胶来接触受伤区域。采用具有可定制图案的紫外线掩模将 GelMA 水凝胶塑造成复制各个伤口区域的定制几何形状,从而将粘附和抗粘附特性集成到同一个贴片中。此外,还加载血管内皮生长因子以加速愈合过程。基于这些优点,作者证明本发明的贴片不仅粘附于不同的皮肤表面,而且还促进了大鼠皮肤伤口模型的治疗。因此,相信这种多功能贴剂可以突破传统贴剂的限制,成为伤口愈合和相关生物医学应用的理想选择。
更新日期:2021-09-09
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