AIM To report on psychomotor development and outcomes in term born neonates with non-epileptic paroxysmal events (NEPEs). METHOD From October 2017 to March 2019 we enrolled 38 consecutive term born neonates (22 males, 16 females; aged between 0-28d), born at the University Hospital San Marco in Catania, Italy, with NEPEs. We performed the Hammersmith Neonatal Neurological Examination scale (at enrolment), the Hammersmith Infant Neurological Examination (HINE) scale (at age 3, 6, 9, and 12mo), and the Griffiths scale (at age 12mo). RESULTS The age at onset of first paroxysmal manifestations ranged from birth to 4 days. We recorded a suboptimal global score in 18 out of 38 patients at enrolment and in 10 out of 38 patients at age 3 months (>70% of these infants were male); all events disappeared within 6 months of life. At age 6, 9, and 12 months, all infants scored within normal values on the HINE and Griffiths scale. INTERPRETATION Patients with NEPEs achieve neurodevelopment optimal scores within their first year of life.

中文翻译：

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新生儿非癫痫阵发性事件的神经发育结局：一项前瞻性研究

目的 报告患有非癫痫发作性事件 (NEPE) 的足月新生儿的心理运动发育和结果。方法 2017 年 10 月至 2019 年 3 月，我们连续招募了 38 名出生在意大利卡塔尼亚圣马可大学医院的 NEPE 足月新生儿（男 22 例，女 16 例；年龄在 0-28 天之间）。我们进行了 Hammersmith 新生儿神经学检查量表（入学时）、Hammersmith 婴儿神经学检查 (HINE) 量表（3、6、9 和 12 个月）和 Griffiths 量表（12 个月时）。结果 首次出现阵发性表现的年龄从出生到 4 天不等。我们在入组时记录了 38 名患者中的 18 名和 3 个月大时 38 名患者中的 10 名（这些婴儿中 >70% 是男性）的次优总体评分；所有事件在出生后 6 个月内消失。在 6、9 和 12 个月大时，所有婴儿的 HINE 和 Griffiths 量表均在正常值范围内。解释 NEPE 患者在其生命的第一年内达到神经发育最佳评分。