Air quality, Environment and Respiratory Outcomes in Bronchopulmonary Dysplasia, the AERO-BPD cohort study: design and adaptation during the SARS-CoV-2 pandemic,BMJ Open Respiratory Research

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Air quality, Environment and Respiratory Outcomes in Bronchopulmonary Dysplasia, the AERO-BPD cohort study: design and adaptation during the SARS-CoV-2 pandemic
BMJ Open Respiratory Research ( IF 4.1 ) Pub Date : 2021-06-01 , DOI: 10.1136/bmjresp-2021-000915
Hana B Ruran ₁ , Gary Adamkiewicz ₂ , Amparito Cunningham ₃ , Carter R Petty ₄ , Kimberly F Greco ₄ , Sigfus Gunnlaugsson _{1,

5} , Natalie Stamatiadis ₁ , Gabriella Sierra ₁ , Jose Vallarino ₂ , Marty Alvarez ₂ , Lystra P Hayden _{1,

5} , Catherine A Sheils _{1,

5} , Edie Weller _{4,

5} , Wanda Phipatanakul _{3,

5} , Jonathan M Gaffin _{5,

6}

Affiliation

Introduction Almost half of all school-age children with bronchopulmonary dysplasia (BPD) have asthma-like symptoms and more suffer from lung function deficits. While air pollution and indoor respiratory irritants are known to affect high-risk populations of children, few studies have objectively evaluated environmental contributions to long-term respiratory morbidity in this population. This study aimed to examine the role of indoor environmental exposures on respiratory morbidity in children with BPD. Methods and analysis The Air quality, Environment and Respiratory Ouctomes in BPD (AERO-BPD) study is a prospective, single-centre observational study that will enrol a unique cohort of 240 children with BPD and carefully characterise participants and their indoor home environmental exposures. Measures of indoor air quality constituents will assess the relationship of nitrogen dioxide (NO2), particulate matter (PM2.5), nitric oxide (NO), temperature and humidity, as well as dust concentrations of allergens, with concurrently measured respiratory symptoms and lung function. Adaptations to the research protocol due to the SARS-CoV-2 pandemic included remote home environment and participant assessments. Ethics and dissemination Study protocol was approved by the Boston Children’s Hospital Committee on Clinical Investigation. Dissemination will be in the form of peer-reviewed publications and participant information products. Trial registration number [NCT04107701][1]. [1]: /lookup/external-ref?link_type=CLINTRIALGOV&access_num=NCT04107701&atom=%2Fbmjresp%2F8%2F1%2Fe000915.atom

中文翻译：

支气管肺发育不良的空气质量、环境和呼吸结果，AERO-BPD 队列研究：SARS-CoV-2 大流行期间的设计和适应

简介几乎一半患有支气管肺发育不良 (BPD) 的学龄儿童有类似哮喘的症状，更多人患有肺功能缺陷。虽然已知空气污染和室内呼吸道刺激物会影响儿童高危人群，但很少有研究客观评估环境对该人群长期呼吸道疾病的影响。本研究旨在探讨室内环境暴露对 BPD 儿童呼吸道疾病发病率的影响。方法和分析 BPD 中的空气质量、环境和呼吸系统 (AERO-BPD) 研究是一项前瞻性、单中心观察性研究，将招募 240 名 BPD 儿童组成的独特队列，并仔细描述参与者及其室内环境暴露的特征。室内空气质量成分的测量将评估二氧化氮（NO2）、颗粒物（PM2.5）、一氧化氮（NO）、温度和湿度以及过敏原粉尘浓度的关系，同时测量呼吸道症状和肺部症状功能。由于 SARS-CoV-2 大流行，对研究方案的调整包括远程家庭环境和参与者评估。伦理和传播研究方案得到了波士顿儿童医院临床研究委员会的批准。传播将以同行评审出版物和参与者信息产品的形式进行。试用注册号[NCT04107701][1]。[1]: /lookup/external-ref?link_type=CLINTRIALGOV&access_num=NCT04107701&atom=%2Fbmjresp%2F8%2F1%2Fe000915.atom

更新日期：2021-06-30

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