Mice are the most commonly used model organism for human biology, and failure to acknowledge fundamental differences in thermal biology between these species has confounded the study of adipose tissue metabolism in mice and its translational relevance to humans. Here, using exercise biochemistry as an example, we highlight the subtle yet detrimental effects sub-thermoneutral housing temperatures can have on the study of adipose tissue metabolism in mice. We encourage academics and publishers to consider ambient housing temperature as a key determinant in the methodological conception and reporting of all research on rodent white adipose tissue metabolism.

中文翻译：

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亚中性温度对有氧运动诱导的小鼠皮下白色脂肪组织适应的混杂影响

小鼠是人类生物学最常用的模式生物，未能承认这些物种之间热生物学的根本差异，混淆了小鼠脂肪组织代谢及其与人类转化相关性的研究。在这里，以运动生物化学为例，我们强调了亚中性温度对小鼠脂肪组织代谢研究可能产生的微妙但有害的影响。我们鼓励学者和出版商将环境温度作为所有啮齿动物白色脂肪组织代谢研究的方法概念和报告的关键决定因素。