In addition to the pandemic caused by the coronavirus disease 2019, many pathogenic bacteria have also been posing a devastating threat to human health. The overuse of antibiotics leads to the emergence of ‘superbugs’; therefore, it is urgent to develop effective strategies to fight bacteria. Herein, a superparamagnetic nickel (Ni) colloidal nanocrystal clusters (SNCNCs) that can kill and capture bacteria without any camouflage is reported. It binds to amino groups on the surface of bacteria, imparts magnetism to them, and orients them in response to magnetic fields. SNCNCs kill and capture bacteria to avoid inflammation, infection, and organ damage caused by lipopolysaccharide and exotoxin released by bacterial rupture in the remaining bacterial remains in comparison with other antibacterial agents. In this study, in the treatment of traumatic oral ulcers, we found that SNCNCs could kill and capture and remove bacteria from the ulcers to reduce inflammation at the site of the wound. Furthermore, the fibrin gel sprayed on the ulcer was used as a substrate, and the bacteria captured by the SNCNCs moved to the surface of the fibrin gel after a magnetic field was applied. Therefore, the bacteria in the ulcer could be removed with the SNCNCs and fibrin gel magnet, alleviating inflammation caused by bacteria and promoting ulcer healing. This magnetically controlled method of directional movement of bacteria may provide an applicative perspective for the therapy of bacterial infections.

除了2019年冠状病毒病引起的大流行外，许多病原菌也对人类健康构成了毁灭性的威胁。过度使用抗生素导致“超级细菌”的出现；因此，迫切需要制定有效的策略来对抗细菌。本文报道了一种超顺磁性镍 (Ni) 胶体纳米晶簇 (SNCNCs)，它可以在没有任何伪装的情况下杀死和捕获细菌。它与细菌表面的氨基结合，赋予它们磁性，并根据磁场使它们定向。与其他抗菌剂相比，SNCNCs 杀死和捕获细菌以避免由细菌破裂释放的脂多糖和外毒素引起的炎症、感染和器官损伤。在这项研究中，在外伤性口腔溃疡的治疗中，我们发现 SNCNCs 可以杀死、捕获和清除溃疡中的细菌，以减少伤口部位的炎症。此外，喷洒在溃疡上的纤维蛋白凝胶被用作基质，在施加磁场后，被 SNCNCs 捕获的细菌移动到纤维蛋白凝胶的表面。因此，SNCNCs和纤维蛋白凝胶磁铁可以去除溃疡中的细菌，减轻细菌引起的炎症，促进溃疡愈合。这种细菌定向运动的磁控方法可为细菌感染的治疗提供应用前景。以喷在溃疡上的纤维蛋白凝胶为基质，施加磁场后，被SNCNCs捕获的细菌移动到纤维蛋白凝胶表面。因此，SNCNCs和纤维蛋白凝胶磁铁可以去除溃疡中的细菌，减轻细菌引起的炎症，促进溃疡愈合。这种细菌定向运动的磁控方法可为细菌感染的治疗提供应用前景。以喷在溃疡上的纤维蛋白凝胶为基质，施加磁场后，被SNCNCs捕获的细菌移动到纤维蛋白凝胶表面。因此，SNCNCs和纤维蛋白凝胶磁铁可以去除溃疡中的细菌，减轻细菌引起的炎症，促进溃疡愈合。这种细菌定向运动的磁控方法可为细菌感染的治疗提供应用前景。