Over decades, the prevailing standard in drug discovery was the concept of designing highly selective compounds that act on individual drug targets. However, more recently, multi-target and combinatorial drug therapies have become an important treatment modality in complex diseases , including neurodegenerative diseases such as Alzheimer's and Parkinson's disease. The development of such network-based approaches is facilitated by the significant advance in our understanding of the pathophysiological processes in these and other complex brain diseases and the adoption of modern computational approaches in drug discovery and repurposing. However, although drug combination therapy has become an effective means for the symptomatic treatment of many complex diseases, the holy grail of identifying clinically effective disease-modifying treatments for neurodegenerative and other brain diseases remains elusive. Thus, despite extensive research, there remains an urgent need for novel treatments that will modify the progression of the disease or prevent its development in patients at risk. Here we discuss recent approaches with a focus on multi-targeted drug combinations for prevention or modification of epilepsy. Over the last ∼10 years, several novel promising multi-targeted therapeutic approaches have been identified in animal models. We envision that synergistic combinations of repurposed drugs as presented in this review will be demonstrated to prevent epilepsy in patients at risk within the next 5–10 years.

几十年来，药物发现的普遍标准是设计作用于单个药物靶点的高选择性化合物的概念。然而，最近，多靶点和组合药物疗法已成为复杂疾病的重要治疗方式，包括阿尔茨海默病和帕金森病等神经退行性疾病。我们对这些和其他复杂脑部疾病的病理生理过程的理解取得了重大进展，并且在药物发现和再利用方面采用了现代计算方法，从而促进了这种基于网络的方法的发展。然而，虽然药物联合治疗已成为许多复杂疾病对症治疗的有效手段，为神经退行性疾病和其他脑部疾病确定临床有效的疾病改善疗法的圣杯仍然难以捉摸。因此，尽管进行了广泛的研究，但仍然迫切需要新的治疗方法，以改变疾病的进展或防止其在有风险的患者中发展。在这里，我们讨论了最近的方法，重点是用于预防或改善癫痫的多靶点药物组合。在过去的 10 年里，已经在动物模型中发现了几种新的有前景的多靶向治疗方法。我们设想，本综述中提出的重新利用药物的协同组合将被证明可以在未来 5-10 年内预防高危患者的癫痫症。仍然迫切需要新的治疗方法，以改变疾病的进展或防止其在有风险的患者中发展。在这里，我们讨论了最近的方法，重点是用于预防或改善癫痫的多靶点药物组合。在过去的 10 年里，已经在动物模型中发现了几种新的有前景的多靶向治疗方法。我们设想，本综述中提出的重新利用药物的协同组合将被证明可以在未来 5-10 年内预防高危患者的癫痫症。仍然迫切需要新的治疗方法，以改变疾病的进展或防止其在有风险的患者中发展。在这里，我们讨论了最近的方法，重点是用于预防或改善癫痫的多靶点药物组合。在过去的 10 年里，已经在动物模型中发现了几种新的有前景的多靶向治疗方法。我们设想，本综述中提出的重新利用药物的协同组合将被证明可以在未来 5-10 年内预防高危患者的癫痫症。在过去的 10 年里，已经在动物模型中发现了几种新的有前景的多靶向治疗方法。我们设想，本综述中提出的重新利用药物的协同组合将被证明可以在未来 5-10 年内预防高危患者的癫痫症。在过去的 10 年里，已经在动物模型中发现了几种新的有前景的多靶向治疗方法。我们设想，本综述中提出的重新利用药物的协同组合将被证明可以在未来 5-10 年内预防高危患者的癫痫症。