Over a century of scientific inquiry since the discovery of v-SRC but still no final judgement on SRC function. However, a significant body of work has defined Src family kinases as key players in tumor progression, invasion and metastasis in human cancer. With the ever-growing evidence supporting the role of epithelial-mesenchymal transition (EMT) in invasion and metastasis, so does our understanding of the role SFKs play in mediating these processes. Here we describe some key mechanisms through which Src family kinases play critical role in epithelial homeostasis and how their function is essential for the propagation of invasive signals.

中文翻译：

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上皮间质转化中的 Src 家族激酶、衔接蛋白和肌动蛋白细胞骨架

自发现 v-SRC 以来进行了一个多世纪的科学探索，但仍未对 SRC 功能做出最终判断。然而，大量工作已将 Src 家族激酶定义为人类癌症中肿瘤进展、侵袭和转移的关键参与者。随着越来越多的证据支持上皮间质转化 (EMT) 在侵袭和转移中的作用，我们对 SFK 在介导这些过程中所起的作用的理解也越来越多。在这里，我们描述了 Src 家族激酶在上皮稳态中发挥关键作用的一些关键机制，以及它们的功能如何对侵入信号的传播至关重要。