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T-cell infiltration, contribution and regulation in the central nervous system post-traumatic injury
Cell Proliferation ( IF 8.5 ) Pub Date : 2021-06-29 , DOI: 10.1111/cpr.13092
Lvwan Xu 1 , Xin Ye 2 , Qingyi Wang 1 , Bihan Xu 1 , Jinjie Zhong 3 , Ying-Ying Chen 3 , Lin-Lin Wang 1
Affiliation  

T cells participate in the repair process and immune response in the CNS post-traumatic injury and play both a beneficial and harmful role. Together with nerve cells and other immune cells, they form a microenvironment in the CNS post-traumatic injury. The repair of traumatic CNS injury is a long-term process. T cells contribute to the repair of the injury site to influence the recovery. Recently, with the advance of new techniques, such as mass spectrometry-based flow cytometry, modern live-cell imaging, etc, research focusing on T cells is becoming one of the valuable directions for the future therapy of traumatic CNS injury. In this review, we summarized the infiltration, contribution and regulation of T cells in post-traumatic injury, discussed the clinical significance and predicted the future research direction.

中文翻译:

创伤后中枢神经系统 T 细胞浸润、贡献和调节

T细胞参与中枢神经系统创伤后损伤的修复过程和免疫反应,发挥有益和有害的双重作用。它们与神经细胞和其他免疫细胞一起,在中枢神经系统创伤后损伤中形成微环境。创伤性中枢神经系统损伤的修复是一个长期的过程。T 细胞有助于损伤部位的修复以影响恢复。近年来,随着基于质谱的流式细胞术、现代活细胞成像等新技术的进步,以T细胞为重点的研究正成为未来创伤性中枢神经系统损伤治疗的重要方向之一。本综述总结了T细胞在创伤后损伤中的浸润、贡献和调控,讨论了其临床意义并预测了未来的研究方向。
更新日期:2021-08-09
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