The interest in microfluidic devices is increasing day by day due to consuming much lower amount of chemicals. Paper-based microfluid device is one of the most important types of microfluidic device, due to the inherent superior properties of papers. This study set out to develop a novel approach to fabricate a pH-responsive paper-based microfluidic device using plasma enhanced chemical vapor deposition (PECVD). Magnets were used for masking the paper surface. Poly(2-dimethylaminoethyl methacrylate) (PDMAEMA) thin film having ionizable groups was coated on the inner surfaces of the microfluidic channel. Hydrophobic poly (2,2,3,4,4,4-hexafluoro butyl acrylate) (PHFBA) thin film was used to produce the barrier of the microchannel. A standard chromatography paper was successfully transformed into pH-responsive paper-based microfluidic device. Due to its inherent vapor-based nature, PECVD method provided excellent conformal coverage on the paper surface without disrupting the surface structures. The selective separation ability of the microfluidic device was tested at different pH values using anionic and cationic analytes. The microfluidic device demonstrated selective separation ability of analytes depending on the pH value of the medium. The obtained results showed that the differences between the retentions of both analytes on the microfluidic device at different pH values are much more than those of the uncoated papers under the same conditions.

由于消耗更少的化学品，对微流体装置的兴趣日益增加。由于纸张固有的优越特性，纸基微流体装置是最重要的微流体装置类型之一。本研究着手开发一种使用等离子体增强化学气相沉积 (PECVD) 制造 pH 响应纸基微流体装置的新方法。磁铁用于掩盖纸面。具有可电离基团的聚（2-二甲基氨基乙基甲基丙烯酸酯）（PDMAEMA）薄膜涂覆在微流体通道的内表面。疏水性聚（2,2,3,4,4,4-六氟丙烯酸丁酯）（PHFBA）薄膜用于制造微通道的屏障。标准层析纸成功转化为 pH 响应纸基微流体装置。由于其固有的基于蒸汽的性质，PECVD 方法在不破坏表面结构的情况下在纸张表面提供了出色的保形覆盖。使用阴离子和阳离子分析物在不同 pH 值下测试微流体装置的选择性分离能力。微流体装置根据介质的 pH 值显示出对分析物的选择性分离能力。所得结果表明，在相同条件下，微流控装置上两种分析物在不同 pH 值下的保留差异远大于未涂布纸。使用阴离子和阳离子分析物在不同 pH 值下测试微流体装置的选择性分离能力。微流体装置根据介质的 pH 值显示出对分析物的选择性分离能力。所得结果表明，在相同条件下，微流控装置上两种分析物在不同 pH 值下的保留差异远大于未涂布纸。使用阴离子和阳离子分析物在不同 pH 值下测试微流体装置的选择性分离能力。微流体装置根据介质的 pH 值显示出对分析物的选择性分离能力。所得结果表明，在相同条件下，微流控装置上两种分析物在不同 pH 值下的保留差异远大于未涂布纸。