Antifungal surveillance is an important tool to monitor the prevalence of uncommon fungal species and increasing antifungal resistance throughout the world, but data comparing results across several different Asian countries are scarce. In this study, 372 invasive molds collected in the Asia-Western Pacific region in 2011–2019 were susceptibility tested for mold-active triazoles (isavuconazole, posaconazole, voriconazole, and itraconazole). The collection includes 318 Aspergillus spp. isolates and 53 non-Aspergillus molds. The MIC values using CLSI methods for isavuconazole versus Aspergillus fumigatus ranged from 0.25 to 2 mg l⁻¹. Isavuconazole, itraconazole, posaconazole, and voriconazole acted similarly against A. fumigatus. The mold-active triazoles exhibited a wildtype phenotype to most of the Aspergillus spp. isolates tested (>94%), but poor activity against Fusarium solani species complex and Lomentospora prolificans. Voriconazole was most active against the Scedosporium spp. and posaconazole was most active against the Mucorales. In summary, isavuconazole displayed excellent activity against most species of Aspergillus and was comparable to other mold-active triazoles against non-Aspergillus molds.

抗真菌监测是监测罕见真菌物种流行和全世界抗真菌耐药性增加的重要工具，但比较几个不同亚洲国家的结果的数据很少。在这项研究中，对 2011-2019 年在亚太地区收集的 372 个侵入性霉菌进行了霉菌活性三唑类（艾沙康唑、泊沙康唑、伏立康​​唑和伊曲康唑）的敏感性测试。该系列包括 318种曲霉属。分离和 53 种非曲霉霉菌。使用 CLSI 方法对艾沙康唑与烟曲霉的 MIC 值范围为 0.25 至 2 mg l ^-1。艾沙康唑、伊曲康唑、泊沙康唑和伏立康唑的作用相似A. fumigatus。霉菌活性三唑对大多数曲霉菌属表现出野生型表型。测试的分离株 (>94%)，但对Fusarium solani species complex 和Lomentospora prolificans的活性较差。伏立康唑对Scedosporium spp 的活性最强。泊沙康唑对毛霉目最有效。总之，艾沙康唑显示出对大多数曲霉属物种的优异活性，并且与其他对非曲霉属霉菌具有霉菌活性的三唑相当。