To identify bioactive natural products from various natural resources, such as plants and microorganisms, we investigated programs to screen for compounds that affect several cancer-related cellular signaling pathways, such as BMI1, TRAIL, and Wnt. This review summarizes the results of our recent studies, particularly those involving natural products isolated from microbial resources, such as actinomycetes, obtained from soil samples collected primarily around Chiba, Japan.

中文翻译：

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微生物天然产物癌相关细胞信号的筛选研究

为了从各种自然资源（如植物和微生物）中鉴定具有生物活性的天然产物，我们研究了筛选影响多种癌症相关细胞信号通路（如 BMI1、TRAIL 和 Wnt）的化合物的程序。这篇综述总结了我们最近的研究结果，特别是那些涉及从微生物资源中分离出的天然产物的研究，例如从主要在日本千叶附近收集的土壤样本中获得的放线菌。